Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and
Management of Patients With Thoracic Aortic Disease | Circulation Science Volunteer Warning …

Smooth muscle cell (SMC) loss is the characteristic feature in the pathogenesis of aortic
dissection (AD), and ferroptosis is a novel iron-dependent regulated cell death driven by the …

Thoracic aortic aneurysm (TAA) is a life-threatening vascular disease frequently associated
with underlying genetic causes. An inadequate understanding of human TAA pathogenesis …

The vasa vasorum are a vital microvascular network supporting the outer wall of larger blood
vessels. Although these dynamic microvessels have been studied for centuries, the …

The major function of vascular smooth muscle cells (SMCs) is contraction to regulate blood
pressure and flow. SMC contractile force requires cyclic interactions between SMC α-actin …

The vascular smooth muscle cell (SMC)-specific isoform of α-actin (ACTA2) is a major
component of the contractile apparatus in SMCs located throughout the arterial system …

A predisposition for thoracic aortic aneurysms leading to acute aortic dissections can be
inherited in families in an autosomal dominant manner. Genome-wide linkage analysis of …

Genetic predisposition and risk factors such as hypertension and smoking can instigate the
development of thoracic aortic aneurysm (TAA), which can lead to highly lethal aortic wall …

Vascular inflammation contributes to cardiovascular diseases such as aortic aneurysm and
dissection. However, the precise inflammatory pathways involved have not been clearly …