Cancer is the leading disease-related cause of death in children in developed countries.
Arising in the context of actively growing tissues, childhood cancers are fundamentally …

In children, cancer probably arises from a combination of inherited genetic mutations and
genetic alterations that are acquired during the rapid cellular expansion that occurs during …

Acute myeloid leukemia (AML) with t (8; 21) or inv (16) have been recognized as unique
entities within AML and are usually reported together as core binding factor AML (CBF …

Identical infant twins with concordant leukemia were first described in 1882, and since that
time many such pairs of infants and older children have been described. It has long been …

Benzene is a ubiquitous chemical in our environment that causes acute leukemia and
probably other hematological cancers. Evidence for an association with childhood leukemia …

Although the identification of cancer stem cells as therapeutic targets is now actively being
pursued in many human malignancies, the leukemic stem cells in acute myeloid leukemia …

Many cancers seem to depend on a small population of'cancer stem cells' for their continued
growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be …

Chromosome translocations are often early or initiating events in leukaemogenesis,
occurring prenatally in most cases of childhood leukaemia. Although these genetic changes …

Studies on monozygotic twins with concordant leukemia and retrospective scrutiny of
neonatal blood spots of patients with leukemia indicate that chromosomal translocations …

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