Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

Abstract Adult marrow‐derived Mesenchymal Stem Cells (MSCs) are capable of dividing
and their progeny are further capable of differentiating into one of several mesenchymal …

Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet the
functional contributions of these cells to tumorigenesis are poorly understood. Using a …

Angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signalling
pathways are affording demonstrable therapeutic efficacy in mouse models of cancer and in …

Upon activation, platelets secrete more than 300 active substances from their intracellular
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …

Several vascular endothelial growth factor (VEGF)-targeted agents, administered either as
single agents or in combination with chemotherapy, have been shown to benefit patients …

Development of hypoxic regions is an indicator of poor prognosis in many tumors. Here, we
demonstrate that HIF1α, the direct effector of hypoxia, partly through increases in SDF1α …

The CXC chemokine CXCL12 is an important factor in physiological and pathological
processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation …

Nanoscale materials have been extensively employed for diagnostic and therapeutic
purposes. However, the developed nanosystems still suffer from some limitations, namely …

Tumors are highly complex tissues composed of neoplastic cells and, in the case of
carcinomas, stromal cell compartments containing a variety of mesenchymal cells, notably …