Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis

Z Lyu, Y Hu, Y Guo, D Liu - Bone research, 2023 - nature.com
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being
of the host. Recent studies have demonstrated that the GM may significantly influence bone …

Gut microbiota functions: metabolism of nutrients and other food components

I Rowland, G Gibson, A Heinken, K Scott… - European journal of …, 2018 - Springer
The diverse microbial community that inhabits the human gut has an extensive metabolic
repertoire that is distinct from, but complements the activity of mammalian enzymes in the …

[HTML][HTML] Hydrogen sulfide: An endogenous regulator of the immune system

N Dilek, A Papapetropoulos, T Toliver-Kinsky… - Pharmacological …, 2020 - Elsevier
Hydrogen sulfide (H 2 S) is now recognized as an endogenous signaling gasotransmitter in
mammals. It is produced by mammalian cells and tissues by various enzymes …

The gut-bone axis: how bacterial metabolites bridge the distance

MM Zaiss, RM Jones, G Schett, R Pacifici - The Journal of clinical …, 2019 - jci.org
The gut microbiome is a key regulator of bone health that affects postnatal skeletal
development and skeletal involution. Alterations in microbiota composition and host …

Microbiota metabolites in health and disease

JL McCarville, GY Chen, VD Cuevas… - Annual review of …, 2020 - annualreviews.org
Metabolism is one of the strongest drivers of interkingdom interactions—including those
between microorganisms and their multicellular hosts. Traditionally thought to fuel energy …

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

JL Wallace, R Wang - Nature reviews Drug discovery, 2015 - nature.com
Hydrogen sulfide (H2S) has become recognized as an important signalling molecule
throughout the body, contributing to many physiological and pathological processes. In …

High fat diet, gut microbiome and gastrointestinal cancer

Y Tong, H Gao, Q Qi, X Liu, J Li, J Gao, P Li… - …, 2021 - pmc.ncbi.nlm.nih.gov
Gastrointestinal cancer is currently one of the main causes of cancer death, with a large
number of cases and a wide range of lesioned sites. A high fat diet, as a public health …

[HTML][HTML] Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies

H Lin, Y Yu, L Zhu, N Lai, L Zhang, Y Guo, X Lin… - Redox biology, 2023 - Elsevier
Hydrogen sulfide (H 2 S) is an important signaling molecule in colorectal cancer (CRC). It is
produced in the colon by the catalytic synthesis of the colonocytes' enzymatic systems and …

[HTML][HTML] Hydrogen sulfide signaling in mitochondria and disease

B Murphy, R Bhattacharya, P Mukherjee - The FASEB Journal, 2019 - pmc.ncbi.nlm.nih.gov
Hydrogen sulfide can signal through 3 distinct mechanisms: 1) reduction and/or direct
binding of metalloprotein heme centers, 2) serving as a potent antioxidant through reactive …