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Ecology and evolution of metabolic cross-feeding interactions in bacteria
Literature covered: early 2000s to late 2017 Bacteria frequently exchange metabolites with
other micro-and macro-organisms. In these often obligate cross-feeding interactions, primary …
other micro-and macro-organisms. In these often obligate cross-feeding interactions, primary …
Fitness costs of plasmids: a limit to plasmid transmission
Plasmids mediate the horizontal transmission of genetic information between bacteria,
facilitating their adaptation to multiple environmental conditions. An especially important …
facilitating their adaptation to multiple environmental conditions. An especially important …
Verrucomicrobia use hundreds of enzymes to digest the algal polysaccharide fucoidan
A Sichert, CH Corzett, MS Schechter, F Unfried… - Nature …, 2020 - nature.com
Brown algae are important players in the global carbon cycle by fixing carbon dioxide into 1
Gt of biomass annually, yet the fate of fucoidan—their major cell wall polysaccharide …
Gt of biomass annually, yet the fate of fucoidan—their major cell wall polysaccharide …
Burden-driven feedback control of gene expression
Cells use feedback regulation to ensure robust growth despite fluctuating demands for
resources and differing environmental conditions. However, the expression of foreign …
resources and differing environmental conditions. However, the expression of foreign …
Understanding the impacts of bacteriophage viruses: from laboratory evolution to natural ecosystems
Viruses of bacteria (bacteriophages or phage) have broad effects on bacterial ecology and
evolution in nature that mediate microbial interactions, shape bacterial diversity, and …
evolution in nature that mediate microbial interactions, shape bacterial diversity, and …
The cost of protein production
The economy of protein production is central to cell physiology, being intimately linked with
cell division rate and cell size. Attempts to model cellular physiology are limited by the …
cell division rate and cell size. Attempts to model cellular physiology are limited by the …
Measuring the burden of hundreds of BioBricks defines an evolutionary limit on constructability in synthetic biology
N Radde, GA Mortensen, D Bhat, S Shah… - Nature …, 2024 - nature.com
Engineered DNA will slow the growth of a host cell if it redirects limiting resources or
otherwise interferes with homeostasis. Escape mutants that alleviate this burden can rapidly …
otherwise interferes with homeostasis. Escape mutants that alleviate this burden can rapidly …
Quantifying cellular capacity identifies gene expression designs with reduced burden
Heterologous gene expression can be a significant burden for cells. Here we describe an in
vivo monitor that tracks changes in the capacity of Escherichia coli in real time and can be …
vivo monitor that tracks changes in the capacity of Escherichia coli in real time and can be …
Glycolytic strategy as a tradeoff between energy yield and protein cost
Contrary to the textbook portrayal of glycolysis as a single pathway conserved across all
domains of life, not all sugar-consuming organisms use the canonical Embden–Meyerhoff …
domains of life, not all sugar-consuming organisms use the canonical Embden–Meyerhoff …
Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria
S Hui, JM Silverman, SS Chen, DW Erickson… - Molecular systems …, 2015 - embopress.org
A central aim of cell biology was to understand the strategy of gene expression in response
to the environment. Here, we study gene expression response to metabolic challenges in …
to the environment. Here, we study gene expression response to metabolic challenges in …