Ecology and evolution of metabolic cross-feeding interactions in bacteria

G D'Souza, S Shitut, D Preussger, G Yousif… - Natural product …, 2018 - pubs.rsc.org
Literature covered: early 2000s to late 2017 Bacteria frequently exchange metabolites with
other micro-and macro-organisms. In these often obligate cross-feeding interactions, primary …

Fitness costs of plasmids: a limit to plasmid transmission

A San Millan, RC MacLean - Microbiology spectrum, 2017 - journals.asm.org
Plasmids mediate the horizontal transmission of genetic information between bacteria,
facilitating their adaptation to multiple environmental conditions. An especially important …

Verrucomicrobia use hundreds of enzymes to digest the algal polysaccharide fucoidan

A Sichert, CH Corzett, MS Schechter, F Unfried… - Nature …, 2020 - nature.com
Brown algae are important players in the global carbon cycle by fixing carbon dioxide into 1
Gt of biomass annually, yet the fate of fucoidan—their major cell wall polysaccharide …

Burden-driven feedback control of gene expression

F Ceroni, A Boo, S Furini, TE Gorochowski… - Nature …, 2018 - nature.com
Cells use feedback regulation to ensure robust growth despite fluctuating demands for
resources and differing environmental conditions. However, the expression of foreign …

Understanding the impacts of bacteriophage viruses: from laboratory evolution to natural ecosystems

B Koskella, CA Hernandez… - Annual Review of …, 2022 - annualreviews.org
Viruses of bacteria (bacteriophages or phage) have broad effects on bacterial ecology and
evolution in nature that mediate microbial interactions, shape bacterial diversity, and …

The cost of protein production

M Kafri, E Metzl-Raz, G Jona, N Barkai - Cell reports, 2016 - cell.com
The economy of protein production is central to cell physiology, being intimately linked with
cell division rate and cell size. Attempts to model cellular physiology are limited by the …

Measuring the burden of hundreds of BioBricks defines an evolutionary limit on constructability in synthetic biology

N Radde, GA Mortensen, D Bhat, S Shah… - Nature …, 2024 - nature.com
Engineered DNA will slow the growth of a host cell if it redirects limiting resources or
otherwise interferes with homeostasis. Escape mutants that alleviate this burden can rapidly …

Quantifying cellular capacity identifies gene expression designs with reduced burden

F Ceroni, R Algar, GB Stan, T Ellis - Nature methods, 2015 - nature.com
Heterologous gene expression can be a significant burden for cells. Here we describe an in
vivo monitor that tracks changes in the capacity of Escherichia coli in real time and can be …

Glycolytic strategy as a tradeoff between energy yield and protein cost

A Flamholz, E Noor, A Bar-Even… - Proceedings of the …, 2013 - pnas.org
Contrary to the textbook portrayal of glycolysis as a single pathway conserved across all
domains of life, not all sugar-consuming organisms use the canonical Embden–Meyerhoff …

Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria

S Hui, JM Silverman, SS Chen, DW Erickson… - Molecular systems …, 2015 - embopress.org
A central aim of cell biology was to understand the strategy of gene expression in response
to the environment. Here, we study gene expression response to metabolic challenges in …