Highlights•Brief history and background of Generative AI (GenAI).•Applications of GenAI in
drug design.•Representations of molecules in GenAI.•Importance of databases in …

The advent of artificial intelligence (AI) has catalyzed a profound transformation in the
pharmaceutical industry, ushering in a paradigm shift across various domains, including …

Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Large-scale proteomics studies can refine our understanding of health and disease and
enable precision medicine. Here, we provide a detailed atlas of 2,920 plasma proteins …

G protein-coupled receptors (GPCRs) are membrane-spanning transducers mediating the
actions of numerous physiological ligands and drugs. The GPCR database GPCRdb …

Around two-thirds of chronic human disease can not be explained by genetics alone. The
Lancet Commission on Pollution and Health estimates that 16% of global premature deaths …

High-throughput omics technologies have dramatically changed biological research,
providing unprecedented insights into the complexity of living systems. This review presents …

Traditional de novo drug discovery, which typically presents an 11% approval rate from
phase I trials and even higher failure rates in fields like neurodegeneration, often requires …

As a free radical and endogenous effector molecule, mammalian endogenous nitric oxide
(NO) is mainly derived from nitric oxide synthase (NOS) via L-arginine. NO participates in …

Locked nucleic acids (LNAs) are a subtype of antisense oligonucleotides (ASOs) that are
characterized by a bridge within the sugar moiety. LNAs owe their robustness to this …