Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …

All mammalian cell membranes contain cholesterol to maintain membrane integrity. The
transport of this hydrophobic lipid is mediated by lipoproteins. Cholesterol is especially …

Spatial molecular profiling of complex tissues is essential to investigate cellular function in
physiological and pathological states. However, methods for molecular analysis of large …

The distribution of brain aerobic glycolysis (AG) in normal young adults correlates spatially
with amyloid-beta (Aβ) deposition in individuals with symptomatic and preclinical Alzheimer …

Progression of Alzheimer's disease (AD) entails deterioration or aberrant function of multiple
brain cell types, eventually leading to neurodegeneration and cognitive decline. Defining …

Extracellular vesicles (EVs) have recently emerged as versatile elements of cell
communication in the nervous system, mediating tissue homeostasis. EVs influence the …

Non-neuronal responses in neurodegenerative disease have received increasing attention
as important contributors to disease pathogenesis and progression. Here we utilize single …

Alzheimer's disease (AD) is characterised by synaptic dysfunction accompanied by the
microscopically visible accumulation of pathological protein deposits and cellular dystrophy …

Amyloid-beta (Aβ) plays an important role in the pathogenesis of Alzheimer's disease.
Aberrant Aβ accumulation induces neuroinflammation, cerebrovascular alterations, and …

Aging affects almost all the aspects of brain functions, but the mechanisms remain largely
undefined. Increasing number of literatures have manifested the important role of glial cells …