Technology of deep brain stimulation: current status and future directions

JK Krauss, N Lipsman, T Aziz, A Boutet… - Nature Reviews …, 2021 - nature.com
Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based
neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and …

Emerging technologies for improved deep brain stimulation

H Cagnan, T Denison, C McIntyre, P Brown - Nature biotechnology, 2019 - nature.com
Deep brain stimulation (DBS) is an effective treatment for common movement disorders and
has been used to modulate neural activity through delivery of electrical stimulation to key …

Deep brain stimulation in movement disorders: from experimental surgery to evidence‐based therapy

P Krack, J Volkmann, G Tinkhauser… - Movement …, 2019 - Wiley Online Library
Deep brain stimulation (DBS) of 3 different targets is the most important therapeutic
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …

Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions

WJ Neumann, LA Steiner, L Milosevic - Brain, 2023 - academic.oup.com
Deep brain stimulation is a neuromodulatory treatment for managing the symptoms of
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …

Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson's disease

M Muthuraman, M Bange, N Koirala, D Ciolac, B Pintea… - Brain, 2020 - academic.oup.com
The disruption of pathologically enhanced beta oscillations is considered one of the key
mechanisms mediating the clinical effects of deep brain stimulation on motor symptoms in …

[HTML][HTML] The sensitivity of ECG contamination to surgical implantation site in brain computer interfaces

WJ Neumann, MM Sorkhabi, M Benjaber, LK Feldmann… - Brain Stimulation, 2021 - Elsevier
Background Brain sensing devices are approved today for Parkinson's, essential tremor,
and epilepsy therapies. Clinical decisions for implants are often influenced by the premise …

Machine learning for adaptive deep brain stimulation in Parkinson's disease: closing the loop

AM Oliveira, L Coelho, E Carvalho… - Journal of …, 2023 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease bearing a
severe social and economic impact. So far, there is no known disease modifying therapy …

[HTML][HTML] Local field potential activity dynamics in response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease

C Wiest, G Tinkhauser, A Pogosyan, M Bange… - Neurobiology of …, 2020 - Elsevier
Local field potentials (LFPs) may afford insight into the mechanisms of action of deep brain
stimulation (DBS) and potential feedback signals for adaptive DBS. In Parkinson's disease …

Neural signatures of indirect pathway activity during subthalamic stimulation in Parkinson's disease

LA Steiner, D Crompton, S Sumarac, A Vetkas… - Nature …, 2024 - nature.com
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) produces an
electrophysiological signature called evoked resonant neural activity (ERNA); a high …

[HTML][HTML] Evoked potentials generated by deep brain stimulation for Parkinson's disease

J Dale, SL Schmidt, K Mitchell, DA Turner, WM Grill - Brain stimulation, 2022 - Elsevier
Background and objectives The goal of this review is to describe the general features,
mechanisms, technical recording factors, and clinical applications of brain evoked potentials …