Nuclear receptors (NRs) are ligand-dependent transcription factors whose activation affects
genes controlling vital processes. Among them, the peroxisome proliferator-activated …

Virulent Mycobacterium tuberculosis inhibits apoptosis and triggers necrosis of host
macrophages to evade innate immunity and delay the initiation of adaptive immunity. By …

Accumulation of lipid droplets (also known as lipid bodies or adiposomes) within leukocytes,
epithelial cells, hepatocytes and other non-adipocytic cells is a frequently observed …

During the past decade, there has been a paradigm shift in our understanding of the roles of
intracellular lipid droplets (LDs). New genetic, biochemical and imaging technologies have …

Chronic inflammation in many infectious and metabolic diseases, and some cancers, is
accompanied by the presence of foam cells. These cells form when the intracellular lipid …

Airway macrophages (AMs) play key roles in the maintenance of lung immune tolerance.
Tissue tailored, highly specialised and strategically positioned, AMs are critical sentinels of …

Mycobacterium tuberculosis enhances its survival in macrophages by suppressing immune
responses in part through its complex cell wall structures. Peroxisome proliferator-activated …

While the existence of a special relationship between Mycobacterium tuberculosis (Mtb) and
host lipids has long been known, it remains a challenging enigma. It was clearly established …

The role of peroxisome proliferator–activated receptor α (PPAR-α) in innate host defense is
largely unknown. In this study, we show that PPAR-α is essential for antimycobacterial …

Bacillus Calmette–Guerin (BCG) is a live attenuated form of Mycobacterium bovis that was
developed 100 years ago as a vaccine against tuberculosis (TB) and has been used ever …