Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer

QF Han, WJ Li, KS Hu, J Gao, WL Zhai, JH Yang… - Molecular cancer, 2022 - Springer
Exosomes are well-known key mediators of intercellular communication and contribute to
various physiological and pathological processes. Their biogenesis involves four key steps …

Insight into extracellular vesicle-cell communication: from cell recognition to intracellular fate

L Ginini, S Billan, E Fridman, Z Gil - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) are heterogamous lipid bilayer-enclosed membranous
structures secreted by cells. They are comprised of apoptotic bodies, microvesicles, and …

Fingerprint profiling of glycans on extracellular vesicles via lectin-induced aggregation strategy for precise cancer diagnostics

G Zhang, X Huang, Y Gong, Y Ding… - Journal of the …, 2024 - ACS Publications
Extracellular vesicles (EVs) harbor abundant glycans that mediate various functions, such as
intercellular communication and disease advancement, which play significant roles in …

Protein glycosylation in extracellular vesicles: Structural characterization and biological functions

J Macedo-da-Silva, VF Santiago… - Molecular …, 2021 - Elsevier
Extracellular vesicles (EVs) are lipid bilayer-enclosed particles involved in intercellular
communication, delivery of biomolecules from donor to recipient cells, cellular disposal and …

Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O‐GlcNAcylation of cyclin‐dependent‐like kinase 5

J Wu, Z Tan, H Li, M Lin, Y Jiang, L Liang… - Journal of Pineal …, 2021 - Wiley Online Library
Melatonin helps to maintain circadian rhythm, exerts anticancer activity, and plays key roles
in regulation of glucose homeostasis and energy metabolism. Glycosylation, a form of …

From exosome biogenesis to absorption: key takeaways for cancer research

NCH Lau, JWP Yam - Cancers, 2023 - mdpi.com
Simple Summary Exosomes are nanometer-sized vesicles released by different cells that
are important in the normal functioning of the body. In cancer, exosomes have been found to …

[HTML][HTML] The hidden potential of glycomarkers: Glycosylation studies in the service of cancer diagnosis and treatment

K Grzesik, M Janik, D Hoja-Łukowicz - Biochimica et Biophysica Acta (BBA) …, 2023 - Elsevier
Abstract Changes in the glycosylation process appear early in carcinogenesis and evolve
with the growth and spread of cancer. The correlation of the characteristic glycosylation …

Tumor-derived nanoseeds condition the soil for metastatic organotropism

M Hu, CM Kenific, N Boudreau, D Lyden - Seminars in Cancer Biology, 2023 - Elsevier
Primary tumors secrete a variety of factors to turn distant microenvironments into favorable
and fertile 'soil'for subsequent metastases. Among these 'seeding'factors that initiate pre …

Comprehensive review of MS‐based studies on N‐glycoproteome and N‐glycome of extracellular vesicles

Y Li, J Wang, W Chen, H Lu, Y Zhang - Proteomics, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are lipid bilayer‐enclosed particles that can be released by all
type of cells. Whereas, as one of the most common post‐translational modifications …

Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/miR-1-3p axis in bladder cancer

Z Tan, Y Jiang, L Liang, J Wu, L Cao, X Zhou… - Journal of Experimental …, 2022 - Springer
Background Abnormal glycosylation in a variety of cancer types is involved in tumor
progression and chemoresistance. Glycosyltransferase C1GALT1, the key enzyme in …