Chromatin remodeling complex NuRD in neurodevelopment and neurodevelopmental disorders
A Hoffmann, D Spengler - Frontiers in genetics, 2019 - frontiersin.org
The nucleosome remodeling and deacetylase (NuRD) complex presents one of the major
chromatin remodeling complexes in mammalian cells. Here, we discuss current evidence for …
chromatin remodeling complexes in mammalian cells. Here, we discuss current evidence for …
Impacts of epigenetic processes on the health and productivity of livestock
M Wang, EM Ibeagha-Awemu - Frontiers in Genetics, 2021 - frontiersin.org
The dynamic changes in the epigenome resulting from the intricate interactions of genetic
and environmental factors play crucial roles in individual growth and development …
and environmental factors play crucial roles in individual growth and development …
[HTML][HTML] The nucleosome remodeling and deacetylation complex modulates chromatin structure at sites of active transcription to fine-tune gene expression
S Bornelöv, N Reynolds, M Xenophontos, S Gharbi… - Molecular Cell, 2018 - cell.com
Chromatin remodeling complexes play essential roles in metazoan development through
widespread control of gene expression, but the precise molecular mechanisms by which …
widespread control of gene expression, but the precise molecular mechanisms by which …
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD
To understand how the nucleosome remodeling and deacetylase (NuRD) complex
regulates enhancers and enhancer–promoter interactions, we have developed an approach …
regulates enhancers and enhancer–promoter interactions, we have developed an approach …
Defined conditions for propagation and manipulation of mouse embryonic stem cells
The power of mouse embryonic stem (ES) cells to colonise the develo** embryo has
revolutionised mammalian developmental genetics and stem cell research. This power is …
revolutionised mammalian developmental genetics and stem cell research. This power is …
Single-cell RNA-seq of human induced pluripotent stem cells reveals cellular heterogeneity and cell state transitions between subpopulations
Heterogeneity of cell states represented in pluripotent cultures has not been described at the
transcriptional level. Since gene expression is highly heterogeneous between cells, single …
transcriptional level. Since gene expression is highly heterogeneous between cells, single …
The Lin28/let-7 pathway regulates the mammalian caudal body axis elongation program
The heterochronic genes Lin28a/b and let-7 regulate invertebrate development, but their
functions in patterning the mammalian body plan remain unexplored. Here, we describe …
functions in patterning the mammalian body plan remain unexplored. Here, we describe …
Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4
J Diener, A Baggiolini, M Pernebrink, D Dalcher… - Nature …, 2021 - nature.com
Melanoma cells rely on developmental programs during tumor initiation and progression.
Here we show that the embryonic stem cell (ESC) factor Sall4 is re-expressed in the Tyr …
Here we show that the embryonic stem cell (ESC) factor Sall4 is re-expressed in the Tyr …
H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation
Histone H3 lysine 4 mono-methylation (H3K4me1) marks poised or active enhancers.
KMT2C (MLL3) and KMT2D (MLL4) catalyze H3K4me1, but their histone methyltransferase …
KMT2C (MLL3) and KMT2D (MLL4) catalyze H3K4me1, but their histone methyltransferase …
SALL proteins; common and antagonistic roles in cancer
C Álvarez, A Quiroz, D Benítez-Riquelme, E Riffo… - Cancers, 2021 - mdpi.com
Simple Summary Transcription factors play essential roles in regulating gene expression,
impacting the cell phenotype and function, and in the response of cells to environmental …
impacting the cell phenotype and function, and in the response of cells to environmental …