The activated partial thromboplastin time (APTT) assay is a very common coagulation test,
used for several reasons. The test is conventionally used for assessing the contact factor …

Arterial and venous thromboses are sustained by development of intraluminal thrombi,
respectively, within the venous and arterial systems. The composition and structure of …

Background Four direct oral anticoagulants (DOACs) have been approved for clinical use by
many medicines regulatory agencies around the world. Due to increasing use of these drugs …

Importance Dose-reduced regimens of direct oral anticoagulants (DOACs) may be used for
2 main purposes: dose-adjusted treatment intended as full-intensity anticoagulation (eg, for …

The term “lupus anticoagulant (LA)” identifies a form of antiphospholipid antibodies (aPLs)
causing prolongation of clotting tests in a phospholipid concentration-dependent manner …

We and others have previously highlighted the potential problems with testing of lupus
anticoagulants (LA) in patients on anticoagulant therapy, including most recently as related …

Introduction Lupus anticoagulant (LA) investigation in patients on anticoagulant therapy is
problematic. Rivaroxaban in particular causes significant interference, prolonging both LA …

This is a narrative review of the published evidence for bleeding management in critically ill
patients in different clinical settings in the intensive care unit (ICU). We aimed to describe …

In certain clinical situations, it is necessary to determine whether clinically relevant plasma
levels of direct oral anticoagulants (DOACs) are present. We examined whether qualitative …

Coagulation testing underpins the investigation of hemostasis and/or monitoring of
anticoagulation therapy for prevention and/or treatment of thrombosis related pathology …