Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - Signal transduction and …, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Function and therapeutic value of astrocytes in neurological diseases

HG Lee, MA Wheeler, FJ Quintana - Nature reviews Drug discovery, 2022 - nature.com
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

Neuroinflammation: an astrocyte perspective

HG Lee, JH Lee, LE Flausino… - Science translational …, 2023 - science.org
Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles
in health and disease. Recent technologies have uncovered the functional heterogeneity of …

Astrocyte crosstalk in CNS inflammation

M Linnerbauer, MA Wheeler, FJ Quintana - Neuron, 2020 - cell.com
Astrocytes control multiple processes in the nervous system in health and disease. It is now
clear that specific astrocyte subsets or activation states are associated with specific genomic …

Inflammation in Parkinson's disease: mechanisms and therapeutic implications

M Pajares, A I. Rojo, G Manda, L Boscá, A Cuadrado - Cells, 2020 - mdpi.com
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …

[HTML][HTML] Neuroinflammation and Parkinson's disease—from neurodegeneration to therapeutic opportunities

B Araújo, R Caridade-Silva, C Soares-Guedes… - Cells, 2022 - mdpi.com
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic …

[HTML][HTML] Microglia and astrocyte dysfunction in parkinson's disease

TI Kam, JT Hinkle, TM Dawson, VL Dawson - Neurobiology of disease, 2020 - Elsevier
While glia are essential for regulating the homeostasis in the normal brain, their dysfunction
contributes to neurodegeneration in many brain diseases, including Parkinson's disease …

[HTML][HTML] Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells

L Iovino, ME Tremblay, L Civiero - Journal of pharmacological sciences, 2020 - Elsevier
Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamate
transmission efficiency depends on the correct functionality and expression of a plethora of …

Brain‐targeted liposomes loaded with monoclonal antibodies reduce alpha‐synuclein aggregation and improve behavioral symptoms in Parkinson's disease

M Sela, M Poley, P Mora‐Raimundo… - Advanced …, 2023 - Wiley Online Library
Monoclonal antibodies (mAbs) hold promise in treating Parkinson's disease (PD), although
poor delivery to the brain hinders their therapeutic application. In the current study, it is …

Reactive astrocytes in neurodegenerative diseases

K Li, J Li, J Zheng, S Qin - Aging and disease, 2019 - pmc.ncbi.nlm.nih.gov
Astrocytes, the largest and most numerous glial cells in the central nervous system (CNS),
play a variety of important roles in regulating homeostasis, increasing synaptic plasticity and …