Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and
metabolic adaptation, has been implicated as a process that regulates cancer. Although …

Autophagy is an intracellular self-degradative mechanism which responds to cellular
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …

Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …

Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an
intracellular catabolic degradative process targeting damaged and superfluous cellular …

The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular
redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both …

Autophagy is an essential, conserved lysosomal degradation pathway that controls the
quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It …

RAS proteins are essential components of signalling pathways that emanate from cell
surface receptors. Oncogenic activation of these proteins owing to missense mutations is …

Cancer formation is a complex and highly regulated multi-step process which is highly
dependent of its environment, from the tissue to the patient. This complexity implies the …

Pharmacological challenges to oncogenic Ras-expressing cancer cells have shown a novel
type of cell death, ferroptosis, which requires intracellular iron. In the present study, we …

The mechanisms by which the p53 tumor suppressor acts remain incompletely understood.
To gain new insights into p53 biology, we used high-throughput sequencing to analyze …