PICALM and Alzheimer's disease: an update and perspectives
Genome-wide association studies (GWAS) have identified the PICALM (Phosphatidylinositol
binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus …
binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus …
Sex differences in brain protein expression and disease
Most complex human traits differ by sex, but we have limited insight into the underlying
mechanisms. Here, we investigated the influence of biological sex on protein expression …
mechanisms. Here, we investigated the influence of biological sex on protein expression …
Shared mechanisms across the major psychiatric and neurodegenerative diseases
Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …
however, whether they share pathophysiology is unclear and is the focus of our …
Omics-based biomarkers discovery for Alzheimer's disease
Q Aerqin, ZT Wang, KM Wu, XY He, Q Dong… - Cellular and Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorders presenting with
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …
Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes
Progressive supranuclear palsy (PSP), a rare Parkinsonian disorder, is characterized by
problems with movement, balance, and cognition. PSP differs from Alzheimer's disease (AD) …
problems with movement, balance, and cognition. PSP differs from Alzheimer's disease (AD) …
Identification of candidate DNA methylation biomarkers related to Alzheimer's disease risk by integrating genome and blood methylome data
Alzheimer disease (AD) is a common neurodegenerative disease with a late onset. It is
critical to identify novel blood-based DNA methylation biomarkers to better understand the …
critical to identify novel blood-based DNA methylation biomarkers to better understand the …
Expanding causal genes for Parkinson's disease via multi-omics analysis
XJ Gu, WM Su, M Dou, Z Jiang, QQ Duan… - npj Parkinson's …, 2023 - nature.com
Genome‑wide association studies (GWASs) have revealed numerous loci associated with
Parkinson's disease (PD). However, some potential causal/risk genes were still not revealed …
Parkinson's disease (PD). However, some potential causal/risk genes were still not revealed …
Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorder
Genome-wide association studies (GWAS) have identified several risk loci for post-traumatic
stress disorder (PTSD); however, how they confer PTSD risk remains unclear. We aimed to …
stress disorder (PTSD); however, how they confer PTSD risk remains unclear. We aimed to …
[HTML][HTML] A splicing transcriptome-wide association study identifies novel altered splicing for Alzheimer's disease susceptibility
Alzheimer's disease (AD) is a common neurodegenerative disease in aging individuals.
Alternative splicing is reported to be relevant to AD development while their roles in etiology …
Alternative splicing is reported to be relevant to AD development while their roles in etiology …
SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning
Multiple reference panels of a given tissue or multiple tissues often exist, and multiple
regression methods could be used for training gene expression imputation models for …
regression methods could be used for training gene expression imputation models for …