Docking screens for novel ligands conferring new biology: Miniperspective
It is now plausible to dock libraries of 10 million molecules against targets over several days
or weeks. When the molecules screened are commercially available, they may be rapidly …
or weeks. When the molecules screened are commercially available, they may be rapidly …
Effects of phytochemicals on cellular signaling: reviewing their recent usage approaches
Most of the previous studies in last three decades report evidence of interactions between
the different phytochemicals and the proteins involved in signal transduction pathways using …
the different phytochemicals and the proteins involved in signal transduction pathways using …
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases—Part III: In-silico molecular docking investigations
IV Ogungbe, WN Setzer - Molecules, 2016 - mdpi.com
Malaria, leishmaniasis, Chagas disease, and human African trypanosomiasis continue to
cause considerable suffering and death in develo** countries. Current treatment options …
cause considerable suffering and death in develo** countries. Current treatment options …
[HTML][HTML] Transcriptome analysis of Snow Mountain Garlic for unraveling the organosulfur metabolic pathway
Abstract Snow Mountain Garlic grows in the high altitudes of the Himalayas under low
temperature conditions. It contains various bioactive compounds whose metabolic pathways …
temperature conditions. It contains various bioactive compounds whose metabolic pathways …
Cloning, expression, and characterization of a novel heparinase I from Bacteroides eggerthii
CY Liu, WB Su, LB Guo, YW Zhang - Preparative Biochemistry & …, 2020 - Taylor & Francis
Abstract Heparinase I (Hep I) specifically degrades heparin to oligosaccharide or
unsaturated disaccharide and has been widely used in preparation of low molecular weight …
unsaturated disaccharide and has been widely used in preparation of low molecular weight …
Outwitting an old neglected nemesis: a review on leveraging integrated data-driven approaches to aid in unraveling of leishmanicides of therapeutic potential
The global prevalence of leishmaniasis has increased with skyrocketed mortality in the past
decade. The causative agent of leishmaniasis is Leishmania species, which infects …
decade. The causative agent of leishmaniasis is Leishmania species, which infects …
Pathogenic role of mitogen activated protein kinases in protozoan parasites
P Kaur, N Goyal - Biochimie, 2022 - Elsevier
Protozoan parasites with complex life cycles have high mortality rates affecting billions of
human lives. Available anti-parasitic drugs are inadequate due to variable efficacy, toxicity …
human lives. Available anti-parasitic drugs are inadequate due to variable efficacy, toxicity …
An integrative in silico and in vitro study identifies Leishmania donovani MAP kinase12 as a probable virulence factor
PH Mazire, A Roy - International Immunopharmacology, 2023 - Elsevier
Visceral leishmaniasis (VL), a potentially fatal vector-borne disease caused by the
intracellular protozoan parasite Leishmania donovani, remains a major health problem due …
intracellular protozoan parasite Leishmania donovani, remains a major health problem due …
Targeting malaria protein kinases
Malaria is one of the most impacting public health problems in tropical and subtropical areas
of the globe, with approximately 200 million cases worldwide annually. In the absence of an …
of the globe, with approximately 200 million cases worldwide annually. In the absence of an …
Molecular characterization of recombinant arginase of Leishmania donovani
N Gaur, K Kumar, CL Gupta, JK Saxena - Protein Expression and …, 2019 - Elsevier
Arginase catalyzes the first committed step in the biosynthesis of polyamines that enable cell
growth and hence potential drug target for the treatment of leishmaniasis. The arginase from …
growth and hence potential drug target for the treatment of leishmaniasis. The arginase from …