Targeting ferroptosis opens new avenues for the development of novel therapeutics

S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney

H Bayır, SJ Dixon, YY Tyurina, JA Kellum… - Nature Reviews …, 2023 - nature.com
Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - Signal transduction and …, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Pharmacological inhibition of ferroptosis as a therapeutic target for neurodegenerative diseases and strokes

Y Wang, S Wu, Q Li, H Sun, H Wang - Advanced Science, 2023 - Wiley Online Library
Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …

Ferroptosis in Parkinson's disease: molecular mechanisms and therapeutic potential

X Ding, L Gao, Z Han, S Eleuteri, W Shi, Y Shen… - Ageing research …, 2023 - Elsevier
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …

Ferroptosis: past, present and future

J Li, F Cao, H Yin, Z Huang, Z Lin, N Mao, B Sun… - Cell death & …, 2020 - nature.com
Ferroptosis is a new type of cell death that was discovered in recent years and is usually
accompanied by a large amount of iron accumulation and lipid peroxidation during the cell …

Ferroptosis: principles and significance in health and disease

F Chen, R Kang, D Tang, J Liu - Journal of hematology & oncology, 2024 - Springer
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid
peroxidation, is governed by molecular networks involving diverse molecules and …

Renal clearable ultrasmall single-crystal Fe nanoparticles for highly selective and effective ferroptosis therapy and immunotherapy

H Liang, X Wu, G Zhao, K Feng, K Ni… - Journal of the American …, 2021 - ACS Publications
Iron-based nanoparticles have attracted much attention because of their ability to induce
ferroptosis via a catalyzing Fenton reaction and to further potentiate immunotherapy …

Ferroptosis and its potential role in the physiopathology of Parkinson's Disease

L Mahoney-Sánchez, H Bouchaoui, S Ayton… - Progress in …, 2021 - Elsevier
Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …

Ferroptosis is a type of autophagy-dependent cell death

B Zhou, J Liu, R Kang, DJ Klionsky, G Kroemer… - Seminars in cancer …, 2020 - Elsevier
Macroautophagy (hereafter referred to as autophagy) involves an intracellular degradation
and recycling system that, in a context-dependent manner, can either promote cell survival …