Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …

It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi)
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …

Trypanosoma cruzi (T. cruzi) is a parasite that affects humans and other mammals. T. cruzi
depends on glycolysis as a source of adenosine triphosphate (ATP) supply, and …

Cutaneous leishmaniasis (CL) is a public health problem affecting more than 98 countries
worldwide. No vaccine is available to prevent the disease, and available medical treatments …

Background: Parasitic diseases caused by protozoa, such as Chagas disease,
leishmaniasis, malaria, African trypanosomiasis, amoebiasis, trichomoniasis, and giardiasis …

Leishmania mexicana (L. mexicana) is a causal agent of cutaneous leishmaniasis (CL), a
“Neglected disease”, for which the search for new drugs is a priority. Benzimidazole is a …

Three allosteric glycolytic enzymes, phosphofructokinase, glyceraldehyde-3 phosphate
dehydrogenase and pyruvate kinase, associated with bacterial, parasitic and human …

Incorporating receptor flexibility in small ligand-protein docking still poses a challenge for
proteins undergoing large conformational changes. In the absence of bound structures …

The tunnel region at triosephosphate isomerase (TIM)'s dimer interface, distant from its
catalytic site, is a target site for certain benzothiazole derivatives that inhibit TIM's catalytic …

Background The delineation of intrinsically weak interactions between novel targets and
fragment screening hits has long limited the pace of hit-to-lead evolution. Rho guanine …