Chondrosarcomas are a diverse group of malignant cartilaginous matrix-producing
neoplasms. Conventional chondrosarcomas are a continuum of disease based on the …

Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical
management is highly challenging due to their heterogeneity and insensitivity to current …

Abstract Epigenetic (“above genetics”) modifications can alter the gene expression without
altering the DNA sequence. Aberrant epigenetic regulations in cancer include DNA …

Isocitrate dehydrogenase (IDH) mutations are common genetic abnormalities in glioma,
which result in the accumulation of an “oncometabolite”, D-2-hydroxyglutarate (D-2-HG) …

Bone sarcomas, although rare, are associated with significant morbidity and mortality. The
most frequent primary bone cancers include osteosarcoma, chondrosarcoma and Ewing …

Purpose: Mutations of the isocitrate dehydrogenase (IDH) gene are common genetic
mutations in human malignancies. Increasing evidence indicates that IDH mutations play …

Metabolic rewiring offers novel therapeutic opportunities in cancer. Until recently, there was
scant information regarding soft tissue sarcomas, due to their heterogeneous tissue origin …

Conventional chondrosarcoma of the chest wall is rare, accounting for 15% of cases. Our
purpose was to document clinicopathological, imaging and outcome results from a novel set …

Through a structure-based irreversible drug design approach, we have discovered a highly
potent IDH1-mutant inhibitor compound 16 (IHMT-IDH1-053)(IC 50= 4.7 nM), which displays …

Background Because chondrosarcomas vary widely in their behavior, and because
anticipating their behavior based on histology alone can be challenging, genetic markers …