Environmental risk factors for type 1 diabetes
The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes
in the environment that have been only partially identified. In this Series paper, we critically …
in the environment that have been only partially identified. In this Series paper, we critically …
T cell-mediated beta cell destruction: autoimmunity and alloimmunity in the context of type 1 diabetes
Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …
immune system. Despite improvements in insulin analogs and continuous blood glucose …
Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
T Delong, TA Wiles, RL Baker, B Bradley, G Barbour… - Science, 2016 - science.org
T cell–mediated destruction of insulin-producing β cells in the pancreas causes type 1
diabetes (T1D). CD4 T cell responses play a central role in β cell destruction, but the identity …
diabetes (T1D). CD4 T cell responses play a central role in β cell destruction, but the identity …
LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII
T Maruhashi, I Okazaki, D Sugiura, S Takahashi… - Nature …, 2018 - nature.com
The success of tumor immunotherapy targeting the inhibitory co-receptors PD-1 and CTLA-4
has indicated that many other co-receptors might be potential druggable targets, despite …
has indicated that many other co-receptors might be potential druggable targets, despite …
The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes
JA Pearson, FS Wong, L Wen - Journal of autoimmunity, 2016 - Elsevier
Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …
Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes
C Sorini, I Cosorich, M Lo Conte… - Proceedings of the …, 2019 - National Acad Sciences
Low-grade intestinal inflammation and alterations of gut barrier integrity are found in patients
affected by extraintestinal autoimmune diseases such as type 1 diabetes (T1D), but a direct …
affected by extraintestinal autoimmune diseases such as type 1 diabetes (T1D), but a direct …
Etiology of type 1 diabetes
JA Todd - Immunity, 2010 - cell.com
Recent genetic map** and gene-phenotype studies have revealed the genetic
architecture of type 1 diabetes. At least ten genes so far can be singled out as strong causal …
architecture of type 1 diabetes. At least ten genes so far can be singled out as strong causal …
Integration of genetic and immunological insights into a model of celiac disease pathogenesis
Celiac disease (CD) is a gluten-sensitive enteropathy that develops in genetically
susceptible individuals by exposure to cereal gluten proteins. This review integrates insights …
susceptible individuals by exposure to cereal gluten proteins. This review integrates insights …
Immune cell crosstalk in type 1 diabetes
The development of type 1 diabetes involves a complex interaction between pancreatic β-
cells and cells of both the innate and adaptive immune systems. Analyses of the interactions …
cells and cells of both the innate and adaptive immune systems. Analyses of the interactions …
Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes
G Xu, TD Grimes, TB Grayson, J Chen… - Nature …, 2022 - nature.com
Currently, no oral medications are available for type 1 diabetes (T1D). While our recent
randomized placebo-controlled T1D trial revealed that oral verapamil had short-term …
randomized placebo-controlled T1D trial revealed that oral verapamil had short-term …