Abstract Resveratrol (3, 5, 4′‐trihydroxystilbene) is a nonflavonoid polyphenol that
naturally occurs as phytoalexin. It is produced by plant sources such as grapes, apples …

Glucocorticoids are a class of anti-inflammatory drugs commonly used to treat various ocular
and systemic conditions. Although the role of glucocorticoids in the treatment of numerous …

With the combined purpose of facilitating useful vision over a lifetime, a number of ocular
cells have evolved specialized features not found elsewhere in the body. The trabecular …

The major drainage structures for aqueous humor (AH) are the conventional or trabecular
outflow pathways, which are comprised of the trabecular meshwork (made up by the uveal …

Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

Transforming growth factor-β2 (TGF-β2) is found in increasing amounts in aqueous humor
and reactive optic nerve astrocytes of patients with primary open-angle glaucoma (POAG), a …

Steroids in susceptible individuals can cause a clinical condition similar to primary open-
angle glaucoma. Five percent of the population are high steroid responders and develop an …

The glucocorticoid receptor (GR), including both alternative spliced isoforms (GRα and
GRβ), has been implicated in the development of primary open-angle glaucoma (POAG) …

Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called
steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma …

Resveratrol, a naturally occurring plant polyphenol found in grapes, is the principal
biologically active component in red wine. Clinical studies have shown that resveratrol due …