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The neurovascular unit and systemic biology in stroke—Implications for translation and treatment
Ischaemic stroke is a leading cause of disability and death for which no acute treatments
exist beyond recanalization. The development of novel therapies has been repeatedly …
exist beyond recanalization. The development of novel therapies has been repeatedly …
What is the evidence for endovascular thrombectomy in posterior circulation stroke?
Posterior circulation infarcts comprise approximately 25% of ischemic strokes but are less
often treated with recanalization therapy and have longer treatment delays compared with …
often treated with recanalization therapy and have longer treatment delays compared with …
Current status of endovascular treatment for acute large vessel occlusion in China: a real-world nationwide registry
Background and Purpose: The benefit of endovascular treatment (EVT) for large vessel
occlusion in clinical practice in develo** countries like China needs to be confirmed. The …
occlusion in clinical practice in develo** countries like China needs to be confirmed. The …
Good clinical outcome decreases with number of retrieval attempts in stroke thrombectomy: beyond the first-pass effect
Background and Purpose: Endovascular therapy is the standard of care in the treatment of
acute ischemic stroke due to large-vessel occlusion. Often, more than one retrieval attempt …
acute ischemic stroke due to large-vessel occlusion. Often, more than one retrieval attempt …
Thrombectomy in extensive stroke may not be beneficial and is associated with increased risk for hemorrhage
L Meyer, M Bechstein, M Bester, U Hanning… - Stroke, 2021 - ahajournals.org
Background and Purpose: This study evaluates the benefit of endovascular treatment (EVT)
for patients with extensive baseline stroke compared with best medical treatment. Methods …
for patients with extensive baseline stroke compared with best medical treatment. Methods …
Number of retrieval attempts rather than procedure time is associated with risk of symptomatic intracranial hemorrhage
Background and Purpose: Endovascular therapy is the standard of care in the treatment of
acute ischemic stroke due to large-vessel occlusion. A direct association between the …
acute ischemic stroke due to large-vessel occlusion. A direct association between the …
[HTML][HTML] Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke
Acute cerebral ischemia triggers a profound inflammatory response. While macrophages
polarized to an M2-like phenotype clear debris and facilitate tissue repair, aberrant or …
polarized to an M2-like phenotype clear debris and facilitate tissue repair, aberrant or …
Endovascular treatment of very elderly patients aged≥ 90 with acute ischemic stroke
L Meyer, M Alexandrou, F Flottmann… - Journal of the …, 2020 - ahajournals.org
Background Patients aged≥ 90 were excluded or under‐represented in past thrombectomy
trials; thus, uncertainty remains whether treatment benefits can be expected regardless of …
trials; thus, uncertainty remains whether treatment benefits can be expected regardless of …
[HTML][HTML] Tandem lesions in anterior circulation stroke
Background and Purpose: Tandem lesions in the anterior circulation account for up to 30%
of all large vessel occlusion strokes. The optimal periprocedural approach in these lesions is …
of all large vessel occlusion strokes. The optimal periprocedural approach in these lesions is …
Association between intravenous thrombolysis and clinical outcomes among patients with ischemic stroke and unsuccessful mechanical reperfusion
Importance Clinical evidence of the potential treatment benefit of intravenous thrombolysis
preceding unsuccessful mechanical thrombectomy (MT) is scarce. Objective To determine …
preceding unsuccessful mechanical thrombectomy (MT) is scarce. Objective To determine …