Ever since technologies enabled the characterization of eukaryotic plasma membranes,
heterogeneities in the distributions of its constituents were observed. Over the years this led …

We review the mechanisms responsible for amino acid homeostasis in Saccharomyces
cerevisiae and other fungi. Amino acid homeostasis is essential for cell growth and survival …

The S. cerevisiae plasma membrane H+-ATPase, Pma1, is a P3A-type ATPase and the
primary protein component of the membrane compartment of Pma1 (MCP). Like other …

Extracellular vesicles (EVs) contribute to several pathophysiological processes and appear
as emerging targets for disease diagnosis and therapy. However, successful translation from …

BACKGROUND: Nearly all processes in living cells are pH dependent, which is why
intracellular pH (pHi) is a tightly regulated physiological parameter in all cellular systems …

Melanins are synthesized macromolecules that are found in all biological kingdoms. These
pigments have a myriad of roles that range from microbial virulence to key components of …

Heterologous expression systems based on tobacco BY‐2 cells, Arabidopsis cell cultures,
Xenopus oocytes, Saccharomyces cerevisiae, and human HeLa cells have been used to …

Although the functions and structural roles of sterols have been the subject of numerous
studies, the reasons for the diversity of sterols in the different eukaryotic kingdoms remain …

Many plasma membrane transporters in yeast are endocytosed in response to excess
substrate or certain stresses and degraded in the vacuole. Endocytosis invariably requires …

The concept of transient nanometric domains known as lipid rafts has brought interest to
reassess the validity of the Singer–Nicolson model of a fluid bilayer for cell membranes …