[HTML][HTML] N-linked protein glycosylation in the ER
M Aebi - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2013 - Elsevier
N-linked protein glycosylation in the endoplasmic reticulum (ER) is a conserved two phase
process in eukaryotic cells. It involves the assembly of an oligosaccharide on a lipid carrier …
process in eukaryotic cells. It involves the assembly of an oligosaccharide on a lipid carrier …
Susceptibility of protein therapeutics to spontaneous chemical modifications by oxidation, cyclization, and elimination reactions
L Grassi, C Cabrele - Amino Acids, 2019 - Springer
Peptides and proteins are preponderantly emerging in the drug market, as shown by the
increasing number of biopharmaceutics already approved or under development …
increasing number of biopharmaceutics already approved or under development …
Posttranslational protein modifications in plant metabolism
Posttranslational modifications (PTM s) of proteins greatly expand proteome diversity,
increase functionality, and allow for rapid responses, all at relatively low costs for the cell …
increase functionality, and allow for rapid responses, all at relatively low costs for the cell …
Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods
The expanding field of monoclonal antibody-based pharmaceuticals has triggered
increased interest in analytical characterization of these large proteins and in understanding …
increased interest in analytical characterization of these large proteins and in understanding …
Middle-down analysis of monoclonal antibodies with electron transfer dissociation orbitrap fourier transform mass spectrometry
The rapid growth of approved biotherapeutics, eg, monoclonal antibodies or
immunoglobulins G (IgGs), demands improved techniques for their quality control …
immunoglobulins G (IgGs), demands improved techniques for their quality control …
Proteins in art, archaeology, and paleontology: from detection to identification
S Dallongeville, N Garnier, C Rolando… - Chemical …, 2016 - ACS Publications
Paleontology, archeology, and art history provide crucial information for the understanding
of human evolution throughout ages and its habits. Past animal and plant species are also …
of human evolution throughout ages and its habits. Past animal and plant species are also …
Metamorphism in TDP-43 prion-like domain determines chaperone recognition
J Carrasco, R Antón, A Valbuena… - Nature …, 2023 - nature.com
The RNA binding protein TDP-43 forms cytoplasmic inclusions via its C-terminal prion-like
domain in several neurodegenerative diseases. Aberrant TDP-43 aggregation arises upon …
domain in several neurodegenerative diseases. Aberrant TDP-43 aggregation arises upon …
High-throughput multi-attribute analysis of antibody-drug conjugates enabled by trapped ion mobility spectrometry and top-down mass spectrometry
Antibody-drug conjugates (ADCs) are one of the fastest growing classes of anticancer
therapies. Combining the high targeting specificity of monoclonal antibodies (mAbs) with …
therapies. Combining the high targeting specificity of monoclonal antibodies (mAbs) with …
An improved trypsin digestion method minimizes digestion-induced modifications on proteins
D Ren, GD Pipes, D Liu, LY Shih, AC Nichols… - Analytical …, 2009 - Elsevier
Trypsin digestion can induce artificial modifications such as asparagine deamidation and N-
terminal glutamine cyclization on proteins due to the temperature and the alkaline pH buffers …
terminal glutamine cyclization on proteins due to the temperature and the alkaline pH buffers …
Detection, evaluation and minimization of nonenzymatic deamidation in proteomic sample preparation
Identification of deamidated sites in proteins is commonly used for assignment of N-
glycosylation sites. It is also important for assessing the role of deamidation in vivo …
glycosylation sites. It is also important for assessing the role of deamidation in vivo …