SCF ubiquitin ligase-targeted therapies
The clinical successes of proteasome inhibitors for the treatment of cancer have highlighted
the therapeutic potential of targeting this protein degradation system. However, proteasome …
the therapeutic potential of targeting this protein degradation system. However, proteasome …
Neddylation: a novel modulator of the tumor microenvironment
L Zhou, Y Jiang, Q Luo, L Li, L Jia - Molecular cancer, 2019 - Springer
Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to
substrate proteins, modulates many important biological processes, including …
substrate proteins, modulates many important biological processes, including …
Protein neddylation and its alterations in human cancers for targeted therapy
L Zhou, W Zhang, Y Sun, L Jia - Cellular signalling, 2018 - Elsevier
Neddylation, a post-translational modification that conjugates an ubiquitin-like protein
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …
The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells
S Zhang, X You, Y Zheng, Y Shen… - The Journal of …, 2023 - Am Soc Clin Investig
Ubiquitin-conjugating enzyme E2C (UBE2C) mediates ubiquitylation chain formation via the
K11 linkage. While previous in vitro studies showed that UBE2C plays a growth-promoting …
K11 linkage. While previous in vitro studies showed that UBE2C plays a growth-promoting …
E1 enzymes as therapeutic targets in cancer
Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …
The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness
Neddylation-mediated activation of Cullin-RING E3 Ligases (CRLs) are necessary for the
degradation of specific immune regulatory proteins. However, little is known about how …
degradation of specific immune regulatory proteins. However, little is known about how …
A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer
T Xu, Q Ma, Y Li, Q Yu, P Pan, Y Zheng, Z Li… - … and Targeted Therapy, 2022 - nature.com
Protein neddylation is catalyzed by a neddylation activating enzyme (NAE, E1), an E2
conjugating enzyme, and an E3 ligase. In various types of human cancers, the neddylation …
conjugating enzyme, and an E3 ligase. In various types of human cancers, the neddylation …
Kindlin-2 links mechano-environment to proline synthesis and tumor growth
Cell metabolism is strongly influenced by mechano-environment. We show here that a
fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate …
fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate …
Protein neddylation and its role in health and diseases
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …
Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage
Purpose: Recent studies have shown that the process of protein neddylation was
abnormally activated in several human cancers. However, it is unknown whether and how …
abnormally activated in several human cancers. However, it is unknown whether and how …