Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
Wnt/β-catenin signaling and disease
The WNT signal transduction cascade controls myriad biological phenomena throughout
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a …
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a …
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis
The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …
WNT signaling in bone homeostasis and disease: from human mutations to treatments
R Baron, M Kneissel - Nature medicine, 2013 - nature.com
Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …
Wnt/β-catenin signaling in development and disease
H Clevers - Cell, 2006 - cell.com
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal
transduction cascade over the last two decades. Wnt genes encode small secreted proteins …
transduction cascade over the last two decades. Wnt genes encode small secreted proteins …
Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …
to activate canonical or non-canonical Wnt signaling pathways, which control various …
WNT as a driver and dependency in cancer
The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …
Wnt signaling pathway: A comprehensive review
Wnt signaling is an evolutionary cell‐to‐cell coordination mechanism and it is highly critical
for a variety of physiological processes of an organism's body, including stem cell …
for a variety of physiological processes of an organism's body, including stem cell …
The osteocyte: an endocrine cell… and more
Few investigators think of bone as an endocrine gland, even after the discovery that
osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and …
osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and …
Building strong bones: molecular regulation of the osteoblast lineage
F Long - Nature reviews Molecular cell biology, 2012 - nature.com
The past 15 years have witnessed tremendous progress in the molecular understanding of
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …