[HTML][HTML] Real-time PCR in the microbiology laboratory
IM Mackay - Clinical microbiology and infection, 2004 - Elsevier
Use of PCR in the field of molecular diagnostics has increased to the point where it is now
accepted as the standard method for detecting nucleic acids from a number of sample and …
accepted as the standard method for detecting nucleic acids from a number of sample and …
A toolbox to study liver stage malaria
The first obligatory phase of mammalian infection by Plasmodium parasites, the causative
agents of malaria, occurs in the liver of the host. This stage of Plasmodium infection bears …
agents of malaria, occurs in the liver of the host. This stage of Plasmodium infection bears …
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
Abstract Development of a highly effective vaccine or antibodies for the prevention and
ultimately elimination of malaria is urgently needed. Here we report the isolation of a number …
ultimately elimination of malaria is urgently needed. Here we report the isolation of a number …
The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host
A Coppi, R Natarajan, G Pradel, BL Bennett… - Journal of Experimental …, 2011 - rupress.org
Plasmodium sporozoites make a remarkable journey from the mosquito midgut to the
mammalian liver. The sporozoite's major surface protein, circumsporozoite protein (CSP), is …
mammalian liver. The sporozoite's major surface protein, circumsporozoite protein (CSP), is …
A candidate antibody drug for prevention of malaria
KL Williams, S Guerrero, Y Flores-Garcia, D Kim… - Nature medicine, 2024 - nature.com
Over 75% of malaria-attributable deaths occur in children under the age of 5 years.
However, the first malaria vaccine recommended by the World Health Organization (WHO) …
However, the first malaria vaccine recommended by the World Health Organization (WHO) …
Plasmodium liver stage developmental arrest by depletion of a protein at the parasite–host interface
AK Mueller, N Camargo, K Kaiser… - Proceedings of the …, 2005 - National Acad Sciences
Plasmodium parasites of mammals, including the species that cause malaria in humans,
infect the liver first and develop there into clinically silent liver stages. Liver stages grow and …
infect the liver first and develop there into clinically silent liver stages. Liver stages grow and …
Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand α-galactosylceramide
α-Galactosylceramide (α-GalCer) is a glycolipid that stimulates natural killer T cells to
produce both T helper (Th) 1 and Th2 cytokines. This property enables α-GalCer to …
produce both T helper (Th) 1 and Th2 cytokines. This property enables α-GalCer to …
Plasmodium sporozoites trickle out of the injection site
LM Yamauchi, A Coppi, G Snounou… - Cellular …, 2007 - Wiley Online Library
Plasmodium sporozoites make a remarkable journey from the skin, where they are
deposited by an infected Anopheline mosquito, to the liver, where they invade hepatocytes …
deposited by an infected Anopheline mosquito, to the liver, where they invade hepatocytes …
Natural killer T cell ligand α-galactosylceramide enhances protective immunity induced by malaria vaccines
G Gonzalez-Aseguinolaza, L Van Kaer… - The Journal of …, 2002 - rupress.org
The important role played by CD8+ T lymphocytes in the control of parasitic and viral
infections, as well as tumor development, has raised the need for the development of …
infections, as well as tumor development, has raised the need for the development of …
CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes
The success of immunization with irradiated sporozoites is unparalleled among the current
vaccination approaches against malaria, but its mechanistic underpinnings have yet to be …
vaccination approaches against malaria, but its mechanistic underpinnings have yet to be …