Although the extremely thermophilic archaea (Topt≥ 70° C) may be the most primitive
extant forms of life, they have been studied to a limited extent relative to mesophilic …

Extremophiles and their products have been a major focus of research interest for over 40
years. Through this period, studies of these organisms have contributed hugely to many …

Highlights•We focus on how HHP has influenced the life strategy of marine microorganisms.•
Common adaptation strategy allows microorganisms adapt to HHP like other …

Pyrococcus yayanosii CH1, as the first and only obligate piezophilic hyperthermophilic
microorganism discovered to date, extends the physical and chemical limits of life on Earth …

Going forward, industrial biotechnology must consider non-model metabolic engineering
platforms if it is to have maximal impact. This will include microorganisms that natively …

The mechanisms underpinning the replication of genomic DNA have recently been
challenged in Archaea. Indeed, the lack of origin of replication has no deleterious effect on …

Abstract Replication Protein A (RPA) plays a pivotal role in DNA replication by coating and
protecting exposed single-stranded DNA, and acting as a molecular hub that recruits …

Transcriptomes were analyzed for two related hyperthermophilic archaeal species, the
piezophilic Thermococcus barophilus strain MP and piezosensitive Thermococcus …

Thermus thermophilus is an extremely thermophilic bacterium that is widely used as a model
thermophile, in large part due to its amenability to genetic manipulation. Here we describe a …

Hydrostatic pressure plays a significant role in the distribution of life in the biosphere.
Knowledge of deep-sea piezotolerant and (hyper) piezophilic bacteria and archaea diversity …