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Effects of cadmium exposure on the immune system and immunoregulation
Cadmium (Cd), a biologically non-essential heavy metal, is widespread in the environment,
including the air, water, and soil, and is widely present in foods and quantum dot …
including the air, water, and soil, and is widely present in foods and quantum dot …
CAFs interacting with TAMs in tumor microenvironment to enhance tumorigenesis and immune evasion
Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) are
among the most important and abundant players of the tumor microenvironment. CAFs as …
among the most important and abundant players of the tumor microenvironment. CAFs as …
[HTML][HTML] Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity
The aryl hydrocarbon receptor (AhR) is a sensor of products of tryptophan metabolism and a
potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated …
potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated …
[HTML][HTML] Tumor-associated macrophages in breast cancer: Innocent bystander or important player?
Tumor-associated macrophages (TAMs) are important tumor-promoting cells in the breast
tumor microenvironment. Preclinically TAMs stimulate breast tumor progression, including …
tumor microenvironment. Preclinically TAMs stimulate breast tumor progression, including …
The potential role of synovial cells in the progression and treatment of osteoarthritis
Osteoarthritis (OA), the commonest arthritis, is characterized by the progressive destruction
of cartilage, leading to disability. The Current early clinical treatment strategy for OA often …
of cartilage, leading to disability. The Current early clinical treatment strategy for OA often …
Cancer associated fibroblasts sculpt tumour microenvironment by recruiting monocytes and inducing immunosuppressive PD-1+ TAMs
Fibroblasts turn into cancer associated fibroblasts (CAFs) in the tumour microenvironment.
CAFs have recently attracted attention for their function as a regulator of immune cell …
CAFs have recently attracted attention for their function as a regulator of immune cell …
Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages
Macrophages are dynamic cells that mature under the influence of signals from the local
microenvironment into either classically (M1) or alternatively (M2) activated macrophages …
microenvironment into either classically (M1) or alternatively (M2) activated macrophages …
Convenience versus Biological Significance: Are PMA-Differentiated THP-1 Cells a Reliable Substitute for Blood-Derived Macrophages When Studying in Vitro …
Human peripheral-blood monocytes are used as an established in vitro system for
generating macrophages. For several reasons, monocytic cell lines such as THP-1 have …
generating macrophages. For several reasons, monocytic cell lines such as THP-1 have …
Macrophage polarization in atherosclerosis
The implication of the heterogeneous spectrum of pro-and anti-inflammatory macrophages
(Macs) has been an important area of investigation over the last decade. The polarization of …
(Macs) has been an important area of investigation over the last decade. The polarization of …
[HTML][HTML] Extracellular vesicle activities regulating macrophage-and tissue-mediated injury and repair responses
Q Hu, CJ Lyon, JK Fletcher, W Tang, M Wan… - … Pharmaceutica Sinica B, 2021 - Elsevier
Macrophages are typically identified as classically activated (M1) macrophages and
alternatively activated (M2) macrophages, which respectively exhibit pro-and anti …
alternatively activated (M2) macrophages, which respectively exhibit pro-and anti …