The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of
amino acids like the trace amines p-tyramine and β-phenylethylamine, has proven to be an …

Schizophrenia is a chronic, severe and highly complex mental illness. Current treatments
manage the positive symptoms, yet have minimal effects on the negative and cognitive …

Neuropsychiatric disorders are diseases of the central nervous system (CNS) which are
characterised by complex pathomechanisms that including homeostatic failure, malfunction …

In the context of the structural complexity necessary for a molecule to selectively display a
therapeutical action and the requirements for suitable pharmacokinetics, a robust synthetic …

Cholinergic brain activity plays a significant role in memory. Scopolamine a muscarinic
cholinergic antagonist is known to induce impairment in Morris water maze performance, the …

Tobacco addiction is a chronic disorder that is characterized by craving for tobacco products,
withdrawal upon smoking cessation, and relapse after periods of abstinence. Previous …

Recent findings unveil the pharmacological modulation of imidazoline I 2 receptors (I 2-IR)
as a novel strategy to face unmet medical neurodegenerative diseases. In this work, we …

Post-traumatic stress disorder (PTSD), is a severe anxiety disorder characterized by
associative fear conditioning. Single prolonged stress (SPS) is a widely accepted reliable …

Imidazoline I2 receptors (I2-IR), widely distributed in the CNS and altered in patients that
suffer from neurodegenerative disorders, are orphans from a structural point of view, and …

Imidazoline I 2 receptors (I2-IRs) are altered in Alzheimer's disease (AD) patients and are
associated with analgesia. I2-IRs are not structurally described, and their pharmacological …