The crucial role of pituitary GnRH receptors (GnRH-R) in the control of reproductive
functions is well established. These receptors are the target of GnRH agonists (through …

Importance of the field: Tumor targeting with peptides is based on the discovery that
receptors for many regulatory peptides are overexpressed in tumor cells, compared with …

Studies on glucocorticoid receptor (GR) action typically assess gene responses by long-term
stimulation with synthetic hormones. As corticosteroids are released from adrenal glands in …

Introduction: The major hurdle in the application and delivery of peptide pharmaceuticals is
their rapid in vivo breakdown. Methods: We here combined two approaches to stabilize …

Bioconjugates with receptor-mediated tumor-targeting functions and carrying cytotoxic
agents should enable the specific delivery of chemotherapeutics to malignant tissues, thus …

Prostate cancer is androgen-dependent in its early stages and androgen deprivation
therapy represents the most effective first-line therapeutic approach. However, after an initial …

Targeted delivery of therapeutic and diagnostic agents to cancer sites has significant
potential to improve the therapeutic outcome of treatment while minimizing severe side …

Asteraceae (formerly known as Compositae) is one of the largest families of higher plants,
with more than 1700 genera and approximately 24000 species, which grow in varied …

Elucidation the nano-organization of membrane proteins at/within the plasma membrane is
probably the most demanding and still challenging task in cell biology since requires …

Experimental studies have shown that a variety of chemopreventive plant components affect
tumor initiation, promotion, and progression and the main difference, between botanical …