Development of anti-viral agents using molecular modeling and virtual screening techniques
Computational chemistry has always played a key role in anti-viral drug development. The
challenges and the quickly rising public interest when a virus is becoming a threat has …
challenges and the quickly rising public interest when a virus is becoming a threat has …
Antiviral study on Punica granatum L., Momordica charantia L., Andrographis paniculata Nees, and Melia azedarach L., to human herpes virus-3
D Angamuthu, I Purushothaman, S Kothandan… - European Journal of …, 2019 - Elsevier
Abstract Introduction Human Herpes Virus-3 (Varicella Zoster Virus) causes Chickenpox in
childhood and reactivates after decades of being latent to cause Herpes Zoster in adults …
childhood and reactivates after decades of being latent to cause Herpes Zoster in adults …
Novel C-6 Fluorinated Acyclic Side Chain Pyrimidine Derivatives: Synthesis, 1H and 13C NMR Conformational Studies, and Antiviral and Cytostatic Evaluations
S Prekupec, D Makuc, J Plavec, L Šuman… - Journal of medicinal …, 2007 - ACS Publications
The synthetic route for introduction of a fluoroalkyl (7− 12, 14), fluoroalkenyl (15 and 16),
fluorophenylalkyl (17, 19, 20, and 22), and fluorophenylalkenyl (18, 21) side chain at C-6 of …
fluorophenylalkyl (17, 19, 20, and 22), and fluorophenylalkenyl (18, 21) side chain at C-6 of …
Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study
9-[2-(Thiophosphonomethoxy) ethyl] adenine [S-PMEA, 8] and (R)-9-[2-(
Thiophosphonomethoxy) propyl] adenine [S-PMPA, 9] are acyclic nucleoside …
Thiophosphonomethoxy) propyl] adenine [S-PMPA, 9] are acyclic nucleoside …
Identifying HSV-1 Inhibitors from Natural Compounds via Virtual Screening Targeting Surface Glycoprotein D
Herpes simplex virus (HSV) infections are a worldwide health problem in need of new
effective treatments. Of particular interest is the identification of antiviral agents that act via …
effective treatments. Of particular interest is the identification of antiviral agents that act via …
Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Novel α-Borano-Nucleotide Analogues of 9-[2-(Phosphonomethoxy)ethyl]adenine and (R)-9-[2 …
We describe here the synthesis of 9-[2-(Boranophosphonomethoxy) ethyl] adenine (6a) and
(R)-9-[2-(Boranophosphonomethoxy) propyl] adenine (6b), the first α-boranophosphonate …
(R)-9-[2-(Boranophosphonomethoxy) propyl] adenine (6b), the first α-boranophosphonate …
9-Arylpurines as a novel class of enterovirus inhibitors
L Aguado, HJ Thibaut, EM Priego… - Journal of medicinal …, 2010 - ACS Publications
Here we report on a novel class of enterovirus inhibitors that can be structurally described as
9-arylpurines. These compounds elicit activity against a variety of enteroviruses in the low …
9-arylpurines. These compounds elicit activity against a variety of enteroviruses in the low …
Mechanism of resistance to acyclovir in thymidine kinase mutants from Herpes simplex virus type 1: A computational approach
Herpes simplex virus type 1 (HSV-1) infections affect about two-thirds of the world
population, and the standard treatment consists of acyclovir (ACV) and its analogs, which …
population, and the standard treatment consists of acyclovir (ACV) and its analogs, which …
Synthesis and biological evaluation of iodinated and fluorinated 9-(2-hydroxypropyl) and 9-(2-hydroxyethoxy) methyl purine nucleoside analogues
The novel fluorinated and iodinated purine derivatives containing 9-(2-hydroxypropyl)(1a−
7a and 9a− 13a) and 9-(2-hydroxyethoxymethyl)(1b− 3b, 5b, and 7b− 12c) side chains were …
7a and 9a− 13a) and 9-(2-hydroxyethoxymethyl)(1b− 3b, 5b, and 7b− 12c) side chains were …
Synthesis, 18F‐Radiolabelling and Biological Evaluations of C‐6 Alkylated Pyrimidine Nucleoside Analogues
S Raić‐Malić, A Johayem, SM Ametamey… - … and Nucleic Acids, 2004 - Taylor & Francis
Synthesis of pyrimidine derivatives with a side‐chain attached to the C‐6 of pyrimidine ring
(6–14) is reported. Target compounds 8 and 12 were subjected to in vitro phosphorylation …
(6–14) is reported. Target compounds 8 and 12 were subjected to in vitro phosphorylation …