Indirubin is the crucial ingredient of Danggui Longhui Wan and Qing-Dai, traditional
Chinese medicine herbal formulas used for the therapy of chronic myelocytic leukemia in …

The present review explores the critical role of oxime and oxime ether moieties in enhancing
the physicochemical and anticancer properties of structurally diverse molecular frameworks …

Glycogen synthase kinase-3β (GSK3β) is a pivotal protein kinase implicated in a spectrum of
debilitating diseases, encompassing cancer, diabetes, and neurodegenerative disorders …

Recent studies have shown that monocarbonyl analogues of curcumin (MACs) and 1H-
pyrazole heterocycle both demonstrated promising anticancer activities, in which several …

SARS-CoV-2 rapidly infects millions of people worldwide since December 2019. There is
still no effective treatment for the virus, resulting in the death of more than one million …

Research on compounds derived from, or inspired by, natural compounds as novel
anticancer agents has been a significantly focus in recent years. In this study, we reported …

Background Insufficient solubility and stability of bioactive small molecules as well as poor
biocompatibility may cause low bioavailability and are common obstacles in drug …

Chalcone, a common chemical scaffold of many naturally occurring compounds, has been
widely used as an effective template for drug discovery due to its broad biological activities …

Epigenetic alterations found in all human cancers are promising targets for anticancer
therapy. In this sense, histone deacetylase inhibitors (HDACIs) are interesting anticancer …

Considering the importance of benzothiazepine pharmacophore, an attempt was carried out
to synthesize novel 1, 5-benzothiazepine derivatives using polyethylene glycol-400 (PEG …