The emergence of genetic engineering at the beginning of the 1970′ s opened the era of
biomedical technologies, which aims to improve human health using genetic manipulation …

Cell therapy is emerging as a viable therapy to restore neurological function after stroke.
Many types of stem/progenitor cells from different sources have been explored for their …

Neurological disorders, such as stroke, are triggered by a loss of neurons and glial cells.
Ischemic stroke remains a substantial problem for industrialized countries. Over the previous …

Corneal nerves are mainly derived from the ophthalmic branch of the trigeminal ganglion
(TG). Corneal neuropathy contributes to epithelial degenerative changes in diabetic …

Glial cell line-derived neurotrophic factor (GDNF) gene therapy could offer a disease-
modifying treatment for Parkinson's disease (PD). Here, we report that plasmid DNA …

Viral vectors are a commonly used method for gene therapy because of their highly efficient
transduction of cells. However, many vectors have a small genetic capacity, and their …

Introduction: Develo** a disease-modifying gene therapy for Parkinson's disease (PD)
has been a high priority for over a decade. However, due to the inability of large …

Introduction: The blood–brain barrier (BBB) is like an iron curtain that prevents exogenous
substances, including most drugs, from entering the CNS. Intranasal delivery has been …

Background Tetracycline exerts neuroprotection via suppressing the local inflammation
induced by cerebral ischemia. However, the underlying mechanism is not completely clear …

Oncolytic viruses showed promising therapeutic effect against brain cancer in clinical trials.
To further improve oncolytic viruses' potency against brain cancer, combination of oncolytic …