Advances in pathogenesis and therapeutic strategies for osteoporosis

S Song, Y Guo, Y Yang, D Fu - Pharmacology & therapeutics, 2022 - Elsevier
Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

The gut-bone axis: how bacterial metabolites bridge the distance

MM Zaiss, RM Jones, G Schett… - The Journal of clinical …, 2019 - Am Soc Clin Investig
The gut microbiome is a key regulator of bone health that affects postnatal skeletal
development and skeletal involution. Alterations in microbiota composition and host …

The human gut microbiota: a key mediator of osteoporosis and osteogenesis

KD Seely, CA Kotelko, H Douglas, B Bealer… - International journal of …, 2021 - mdpi.com
An expanding body of research asserts that the gut microbiota has a role in bone
metabolism and the pathogenesis of osteoporosis. This review considers the human gut …

Gut microbiota, immune system, and bone

P D'Amelio, F Sassi - Calcified tissue international, 2018 - Springer
The gut microbiota (GM) is the whole of commensal, symbiotic, and pathogenic
microorganisms living in our intestine. The GM–host interactions contribute to the maturation …

Role of dietary supplements and probiotics in modulating microbiota and bone health: the gut-bone axis

A de Sire, R de Sire, C Curci, F Castiglione, W Wahli - Cells, 2022 - mdpi.com
Osteoporosis is characterized by an alteration of bone microstructure with a decreased bone
mineral density, leading to the incidence of fragility fractures. Around 200 million people are …

The microbial metabolite butyrate stimulates bone formation via T regulatory cell-mediated regulation of WNT10B expression

AM Tyagi, M Yu, TM Darby, C Vaccaro, JY Li… - Immunity, 2018 - cell.com
Nutritional supplementation with probiotics can prevent pathologic bone loss. Here we
examined the impact of supplementation with Lactobacillus rhamnosus GG (LGG) on bone …

The microbiota-gut-bone axis and bone health

Y Tu, R Yang, X Xu, X Zhou - Journal of leukocyte biology, 2021 - academic.oup.com
The gastrointestinal tract is colonized by trillions of microorganisms, consisting of bacteria,
fungi, and viruses, known as the “second gene pool” of the human body. In recent years, the …

Interplay between inflammation and pathological bone resorption: insights into recent mechanisms and pathways in related diseases for future perspectives

MA Terkawi, G Matsumae, T Shimizu… - International Journal of …, 2022 - mdpi.com
Bone is a mineralized and elastic connective tissue that provides fundamental functions in
the human body, including mechanical support to the muscles and joints, protection of vital …

Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice

L Sapra, HY Dar, A Bhardwaj, A Pandey, S Kumari… - Scientific reports, 2021 - nature.com
Osteoporosis is a systemic-skeletal disorder characterized by enhanced fragility of bones
leading to increased rates of fractures and morbidity in large number of populations …

Milk and dairy products: good or bad for human bone? practical dietary recommendations for the prevention and management of osteoporosis

AE Ratajczak, A Zawada, AM Rychter, A Dobrowolska… - Nutrients, 2021 - mdpi.com
Osteoporosis affects women twice as often as men. Additionally, it is estimated that 0.3
million and 1.7 million people have hip fractures in the USA and Europe, respectively …