The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment
is increasingly recognized as a critical factor in cancer progression and the efficacy of …

During tumor growth the extracellular matrix (ECM) undergoes dramatic remodeling. The
normal ECM is degraded and substituted with a tumor-specific ECM, which is often of higher …

Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …

Simple Summary The tumor microenvironment encompasses the cellular and extracellular
matrix components that support and shape the three-dimensional framework in which solid …

Somatic mutation-derived neoantigens are associated with patient survival in breast and
ovarian cancer. These neoantigens are targets for cancer, as shown by the implementation …

Immunotherapy has changed the course of cancer treatment. The initial steps were made
through tumor-specific antibodies that guided the setup of an antitumor immune response. A …

Simple Summary Pancreatic cancer is still burdened with a severe prognosis, despite
advances in the diagnosis and surgical management of this disease. The gut microbiome is …

Immunotherapy has shown promising efficacy in the treatment of a wide range of cancers;
however, it has had little effect on pancreatic cancer. Cancer‐associated fibroblasts (CAFs) …

About one-fourth of patients with pancreatic ductal adenocarcinoma (PDAC) are categorized
as borderline resectable (BR) or locally advanced (LA). Chemotherapy and radiation …

Homologous repair deficiency (HRD) impedes double-strand break repair, which is a
common driver of carcinogenesis. Positive HRD status can be used as theranostic markers …