Vascular smooth muscle cells (VSMCs) are involved in phenotypic switching in
atherosclerosis. This switching is characterized by VSMC dedifferentiation, migration, and …

The platelet-derived growth factor (PDFG) signaling pathway exerts persistent activation in
response to a variety of stimuli and facilitates the progression of hepatic fibrosis. Since this …

Atherosclerosis is the main pathological basis of ischemic cardiovascular and
cerebrovascular diseases and has attracted more attention in recent years. Multiple studies …

For about four decades, platelet-derived growth factors (PDGF) and their receptors have
been the subject of intense research, revealing their roles in embryo development and …

The Group IV phospholipase A2 family is comprised of six intracellular enzymes commonly
called cytosolic phospholipase A2 (cPLA2) α, cPLA2β, cPLA2γ, cPLA2δ, cPLA2ε and …

Vascular smooth muscle cell (SMC) phenotypic modulation plays a key role in
atherosclerosis and is classically defined as a switch from a 'contractile'phenotype to a …

The phenotypic transformation from differentiated to dedifferentiated vascular smooth
muscle cells (VSMCs) plays a crucial role in VSMC proliferation and vascular remodeling in …

The JAK-STAT3 signaling pathway is one of the critical pathways regulating cell
proliferation, differentiation, and apoptosis. Myocardin is regarded as a key mediator for the …

Platelet‐derived growth factors (PDGF) bind to two related receptor tyrosine kinases, which
are encoded by the PDGFRA and PDGFRB genes. Recently, heterozygous PDGFRB …

Dedifferentiation, migration, and proliferation of resident vascular smooth muscle cells
(SMCs) are key components of neointima formation after vascular injury. Activation of signal …