Key considerations for investigating and interpreting autophagy in skeletal muscle
Skeletal muscle plays a crucial role in generating force to facilitate movement. Skeletal
muscle is a heterogenous tissue composed of diverse fibers with distinct contractile and …
muscle is a heterogenous tissue composed of diverse fibers with distinct contractile and …
Age-Associated Differences in Recovery from Exercise-Induced Muscle Damage
Understanding the intricate mechanisms governing the cellular response to resistance
exercise is paramount for promoting healthy aging. This narrative review explored the age …
exercise is paramount for promoting healthy aging. This narrative review explored the age …
Myofibrillar protein synthesis rates are increased in chronically exercised skeletal muscle despite decreased anabolic signaling
The molecular responses to acute resistance exercise are well characterized. However, how
cellular signals change over time to modulate chronic adaptations to more prolonged …
cellular signals change over time to modulate chronic adaptations to more prolonged …
Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats
The tumor suppressor p53 is thought to play a key role in the maintenance of cell size and
homeostasis, but relatively little is known about its role in skeletal muscle. Based on its …
homeostasis, but relatively little is known about its role in skeletal muscle. Based on its …
The molecular signature of the peripheral cannabinoid receptor 1 antagonist AM6545 in adipose, liver and muscle tissue
S Dalle, M Schouten, J Deboutte, E de Lange… - Toxicology and Applied …, 2024 - Elsevier
The endocannabinoid system plays an important role in the regulation of metabolism,
growth and regeneration of peripheral tissues, including liver, adipose and muscle tissue …
growth and regeneration of peripheral tissues, including liver, adipose and muscle tissue …
Interleukin-10 plasmid delivery by polymeric nanocarrier shows efficient and safe tissue repair in acute muscle damage models in mice
We established a custom-designed nanocarrier for in vivo delivery of an immunomodulatory
plasmid capable of facilitating tissue repair in acute muscle damage models in mice. The …
plasmid capable of facilitating tissue repair in acute muscle damage models in mice. The …
Cannabinoid receptor 1 expression is higher in muscle of old vs. young males, and increases upon resistance exercise in older adults
Aged skeletal muscle undergoes metabolic and structural alterations eventually resulting in
a loss of muscle strength and mass, ie age-related sarcopenia. Therefore, novel targets for …
a loss of muscle strength and mass, ie age-related sarcopenia. Therefore, novel targets for …
MSCs-derived apoptotic extracellular vesicles promote muscle regeneration by inducing Pannexin 1 channel-dependent creatine release by myoblasts
Q Ye, X Qiu, J Wang, B Xu, Y Su, C Zheng… - International journal of …, 2023 - nature.com
Severe muscle injury is hard to heal and always results in a poor prognosis. Recent studies
found that extracellular vesicle-based therapy has promising prospects for regeneration …
found that extracellular vesicle-based therapy has promising prospects for regeneration …
Changes in protein fluxes in skeletal muscle during sequential stages of muscle regeneration after acute injury in male mice
A Bizieff, M Cheng, K Chang, H Mohammed, N Ziari… - Scientific Reports, 2024 - nature.com
Abstract Changes in protein turnover play an important role in dynamic physiological
processes, including skeletal muscle regeneration, which occurs as an essential part of …
processes, including skeletal muscle regeneration, which occurs as an essential part of …
The CB1 antagonist Rimonabant improves muscle regeneration and remodels the inflammatory and endocannabinoid profile upon injury in male mice
S Dalle, M Schouten, K Vanderbeke, E Van Parys… - Life Sciences, 2025 - Elsevier
Skeletal muscle regeneration upon injury requires timely activation of inflammatory,
myogenic, fibrotic, apoptotic and anabolic systems. Optimization of these features might …
myogenic, fibrotic, apoptotic and anabolic systems. Optimization of these features might …