ABSTRACT A major focus of current biological studies is to fill the knowledge gaps between
cell, tissue and organism scales. To this end, a wide array of contemporary optical analytical …

Gastrointestinal (GI) cancers, including colorectal, gastric, esophageal, pancreatic, and liver,
are associated with high mortality and morbidity rates worldwide. One of the underlying …

Significance Fluorescence lifetime imaging microscopy (FLIM) of the metabolic co-enzyme
nicotinamide adenine dinucleotide (phosphate)[NAD (P) H] is a popular method to monitor …

Reprogramming tumor‐associated macrophages (TAMs) to an inflammatory phenotype
effectively increases the potential of immune checkpoint blockade (ICB) therapy. Artificial …

Metabolic reprogramming at a cellular level contributes to many diseases including cancer,
yet few assays are capable of measuring metabolic pathway usage by individual cells within …

Simple Summary Use of cancer biomarkers for tumor aggressiveness is an unmet clinical
need. Differentiation of high-risk versus low-risk tumors may guide physicians to select …

Access to electron acceptors supports oxidized biomass synthesis and can be limiting for
cancer cell proliferation, but how cancer cells overcome this limitation in tumors is …

Macrophages are dynamic immune cells that govern both normal tissue function and
disease progression. However, standard methods to measure heterogeneity in macrophage …

Assessment of T-cell response to the tumor is important for diagnosis of the disease and
monitoring of therapeutic efficacy. For this, new non-destructive label-free methods are …

Neural stem cells (NSCs) must exit quiescence to produce neurons; however, our
understanding of this process remains constrained by the technical limitations of current …