This review discusses the current state of the viral metabolism field and gaps in knowledge
that will be important for future studies to investigate. We discuss metabolic rewiring caused …

Within weeks of the first report of acquired immunodeficiency syndrome (AIDS) in 1981, it
was observed that these patients often had Kaposi sarcoma (KS), a hitherto rarely seen skin …

Hypoxia-inducible factor (HIF) is an important transcriptional regulator of cell metabolism
and the adaptation to cellular stress caused by oxygen deficiency (hypoxia). Phagocytic …

Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with three malignancies—
Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's …

The life cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) consists of two phases,
latent and lytic. The virus establishes latency as a strategy for avoiding host immune …

Heterodimeric transcription factor hypoxia inducible factor-1 (HIF-1) functions as a master
regulator of oxygen homeostasis in almost all nucleated mammalian cells. The fundamental …

The search for the etiologic agent for Kaposi sarcoma led to the discovery of Kaposi
sarcoma-associated herpesvirus (KSHV) in 1994. KSHV, also called human herpesvirus-8 …

The hypoxia-inducible transcription factor (HIF-1α) is a major regulator of energy
homeostasis and cellular adaptation to low oxygen stress. Recently, HIF-1α has been …

Kaposi's sarcoma associated herpesvirus (KSHV), like other human herpes viruses,
establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic …

Much has been learned since the discovery of KSHV in 1994 about its epidemiology and
pathology but much of what has been learned has yet to be translated into clinical practice …