CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
Shared and independent roles of CGRP and PACAP in migraine pathophysiology
A Kuburas, AF Russo - The Journal of Headache and Pain, 2023 - Springer
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
From CGRP to PACAP, VIP, and beyond: unraveling the next chapters in migraine treatment
Migraine is a neurovascular disorder that can be debilitating for individuals and society.
Current research focuses on finding effective analgesics and management strategies for …
Current research focuses on finding effective analgesics and management strategies for …
The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target?
Calcitonin gene-related peptide (CGRP)-antagonizing drugs represent a major advance in
migraine treatment. However, up to 50% of patients do not benefit from monoclonal …
migraine treatment. However, up to 50% of patients do not benefit from monoclonal …
Molecular mechanisms of migraine: Nitric oxide synthase and neuropeptides
Migraine is a common condition with disabling attacks that burdens people in the prime of
their working lives. Despite years of research into migraine pathophysiology and …
their working lives. Despite years of research into migraine pathophysiology and …
Transient receptor potential canonical 5 mediates inflammatory mechanical and spontaneous pain in mice
Tactile and spontaneous pains are poorly managed symptoms of inflammatory and
neuropathic injury. Here, we found that transient receptor potential canonical 5 (TRPC5) is a …
neuropathic injury. Here, we found that transient receptor potential canonical 5 (TRPC5) is a …
[HTML][HTML] Role of PACAP in migraine: An alternative to CGRP?
Migraine is a widespread and debilitating neurological condition affecting more than a
billion people worldwide. Thus, more effective migraine therapies are highly needed. In the …
billion people worldwide. Thus, more effective migraine therapies are highly needed. In the …
Pituitary adenylate cyclase-activating polypeptide signalling as a therapeutic target in migraine
Migraine is a disabling neurological disorder that affects more than one billion people
worldwide. The clinical presentation is characterized by recurrent headache attacks, which …
worldwide. The clinical presentation is characterized by recurrent headache attacks, which …
Migraine treatment: Towards new pharmacological targets
M Silvestro, LF Iannone, I Orologio, A Tessitore… - International Journal of …, 2023 - mdpi.com
Migraine is a debilitating neurological condition affecting millions of people worldwide. Until
a few years ago, preventive migraine treatments were based on molecules with pleiotropic …
a few years ago, preventive migraine treatments were based on molecules with pleiotropic …
CGRP-dependent signalling pathways involved in mouse models of GTN-cilostazol-and levcromakalim-induced migraine
Background Knowledge of exact signalling events during migraine attacks is lacking.
Various substances are known to trigger migraine attacks in patients and calcitonin gene …
Various substances are known to trigger migraine attacks in patients and calcitonin gene …