Computer simulations: tools for population and evolutionary genetics
Computer simulations are excellent tools for understanding the evolutionary and genetic
consequences of complex processes whose interactions cannot be analytically predicted …
consequences of complex processes whose interactions cannot be analytically predicted …
The neutral theory of molecular evolution in the genomic era
The neutral theory of molecular evolution has been widely accepted and is the guiding
principle for studying evolutionary genomics and the molecular basis of phenotypic …
principle for studying evolutionary genomics and the molecular basis of phenotypic …
Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain
All attempts at treating strokes by pharmacologically reducing the human brain's
vulnerability to ischaemia have failed, leaving stroke as a leading cause of death, disability …
vulnerability to ischaemia have failed, leaving stroke as a leading cause of death, disability …
Introgression of Neandertal-and Denisovan-like haplotypes contributes to adaptive variation in human Toll-like receptors
Pathogens and the diseases they cause have been among the most important selective
forces experienced by humans during their evolutionary history. Although adaptive alleles …
forces experienced by humans during their evolutionary history. Although adaptive alleles …
Genomic Variation in Natural Populations of Drosophila melanogaster
This report of independent genome sequences of two natural populations of Drosophila
melanogaster (37 from North America and 6 from Africa) provides unique insight into forces …
melanogaster (37 from North America and 6 from Africa) provides unique insight into forces …
Evolutionary history of the Toll-like receptor gene family across vertebrates
G Liu, H Zhang, C Zhao, H Zhang - Genome biology and …, 2020 - academic.oup.com
Adaptation to a wide range of pathogenic environments is a major aspect of the ecological
adaptations of vertebrates during evolution. Toll-like receptors (TLRs) are ancient …
adaptations of vertebrates during evolution. Toll-like receptors (TLRs) are ancient …
Genomic signatures of selective pressures and introgression from archaic hominins at human innate immunity genes
Human genes governing innate immunity provide a valuable tool for the study of the
selective pressure imposed by microorganisms on host genomes. A comprehensive …
selective pressure imposed by microorganisms on host genomes. A comprehensive …
Fifteen years of genomewide scans for selection: trends, lessons and unaddressed genetic sources of complication
Genomewide scans for natural selection (GWSS) have become increasingly common over
the last 15 years due to increased availability of genome‐scale genetic data. Here, we report …
the last 15 years due to increased availability of genome‐scale genetic data. Here, we report …
Population genetic tools for dissecting innate immunity in humans
Innate immunity involves direct interactions between the host and microorganisms, both
pathogenic and symbiotic, so natural selection is expected to strongly influence genes …
pathogenic and symbiotic, so natural selection is expected to strongly influence genes …
Leprosy and the human genome
EA Misch, WR Berrington, JC Vary Jr… - … and molecular biology …, 2010 - Am Soc Microbiol
Despite the availability of effective treatment for several decades, leprosy remains an
important medical problem in many regions of the world. Infection with Mycobacterium …
important medical problem in many regions of the world. Infection with Mycobacterium …