Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Digital health technologies have been in use for many years in a wide spectrum of
healthcare scenarios. This narrative review outlines the current use and the future strategies …

Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position …

Mechanistic modeling in neuroscience aims to explain observed phenomena in terms of
underlying causes. However, determining which model parameters agree with complex and …

Early prediction of cardiotoxicity is critical for drug development. Current animal models
raise ethical and translational questions, and have limited accuracy in clinical risk prediction …

Human-based modelling and simulations are becoming ubiquitous in biomedical science
due to their ability to augment experimental and clinical investigations. Cardiac …

Rationale: The promising clinical benefits of delivering human mesenchymal stem cells
(hMSCs) for treating heart disease warrant a better understanding of underlying …

Key points Induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) capture
patient‐specific genotype–phenotype relationships, as well as cell‐to‐cell variability of …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Impulse propagation in biological tissues is known to be modulated by structural
heterogeneity. In cardiac muscle, improved understanding on how this heterogeneity …