Isothermal nucleic acid amplification techniques are used to detect a variety of molecules
such as RNAs, DNAs and proteins. When compared to the gold standard polymerase chain …

The interaction of Rebeccamycin with calf thymus (ctDNA) in the absence and presence of
H1 was investigated by molecular dynamics, multi-spectroscopic, and cellular techniques …

The interaction between ofloxacin (Oflx) and calf thymus DNA (ct DNA) in the presence and
absence of histone H1 was investigated in Tris buffer (pH= 6.8) using UV–vis absorption and …

Environmental conditions in low-resource areas exert significant pressure on populations,
healthcare personnel, and the tools used for disease diagnosis. Fortunately, advancements …

Recent experiments suggest that cellular crowding facilitates the target search dynamics of
proteins on DNA, the mechanism of which is not yet known. By using large scale computer …

The efficacy and toxicity of drugs depend not only on their potency but also on their ability to
reach the target sites in preference to non-target sites. In this regards destabilization of …

Consumption of excess fluorides through drinking water and its adverse effects on human
health is of global concern. Given that people from at least 25 countries are suffering from …

The interactions of RNA triplex (UA* U) and duplex (AU) with naturally occurring flavonoid
fisetin (FTN) have been examined at pH 7.0 using various spectroscopic, viscometric, and …

Conformational dynamics of macromolecules including enzymes are essential for their
function. The present work reports on the role of essential dynamics in alpha‐chymotrypsin …

Abstract 'Bottom-up', ie, molecule to medicine strategy for the discovery of new drugs takes
enormous time and cost. In most of the cases, inherent toxicity and undesired side effects of …