Schizophrenia, neuroimaging and connectomics
Schizophrenia is frequently characterized as a disorder of brain connectivity. Neuroimaging
has played a central role in supporting this view, with nearly two decades of research …
has played a central role in supporting this view, with nearly two decades of research …
Gray matter abnormalities in major depressive disorder: a meta-analysis of voxel based morphometry studies
BACKGROUND: Voxel-based morphometry (VBM) has been widely used to quantify
structural brain changes associated with Major Depressive Disorder (MDD). While some …
structural brain changes associated with Major Depressive Disorder (MDD). While some …
Progressive reduction in cortical thickness as psychosis develops: a multisite longitudinal neuroimaging study of youth at elevated clinical risk
Background Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms
have been observed to show a steeper rate of cortical gray matter reduction compared with …
have been observed to show a steeper rate of cortical gray matter reduction compared with …
Dendritic spine pathology in schizophrenia
Schizophrenia is a neurodevelopmental disorder whose clinical features include
impairments in perception, cognition and motivation. These impairments reflect alterations in …
impairments in perception, cognition and motivation. These impairments reflect alterations in …
Association of structural magnetic resonance imaging measures with psychosis onset in individuals at clinical high risk for develo** psychosis: an ENIGMA working …
Importance The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …
Cognitive control deficits in schizophrenia: mechanisms and meaning
Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …
presence of positive symptomatology, decades of research highlight the importance of …
Are there progressive brain changes in schizophrenia? A meta-analysis of structural magnetic resonance imaging studies
Background It is well established that schizophrenia is associated with structural brain
abnormalities, but whether these are static or progress over time remains controversial …
abnormalities, but whether these are static or progress over time remains controversial …
Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk
Progressive grey matter loss has been demonstrated among clinical high-risk (CHR)
individuals who convert to psychosis, but it is unknown whether these changes occur prior to …
individuals who convert to psychosis, but it is unknown whether these changes occur prior to …
Long-term follow-up of a group at ultra high risk (“prodromal”) for psychosis: the PACE 400 study
Importance The ultra high-risk (UHR) criteria were introduced to prospectively identify
patients at high risk of psychotic disorder. Although the short-term outcome of UHR patients …
patients at high risk of psychotic disorder. Although the short-term outcome of UHR patients …
Neuroanatomical abnormalities in schizophrenia: a multimodal voxelwise meta-analysis and meta-regression analysis
Despite an increasing number of published voxel based morphometry studies of
schizophrenia, there has been no adequate attempt to examine gray (GM) and white matter …
schizophrenia, there has been no adequate attempt to examine gray (GM) and white matter …