Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives

H Lin, C Liu, A Hu, D Zhang, H Yang, Y Mao - Journal of hematology & …, 2024 - Springer
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …

An update on the molecular biology of glioblastoma, with clinical implications and progress in its treatment

E Verdugo, I Puerto, MÁ Medina - Cancer Communications, 2022 - Wiley Online Library
Glioblastoma multiforme (GBM) is the most aggressive and common malignant primary brain
tumor. Patients with GBM often have poor prognoses, with a median survival of∼ 15 months …

Glioblastoma therapy: Past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

[HTML][HTML] Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

M Liao, D Yao, L Wu, C Luo, Z Wang, J Zhang… - … Pharmaceutica Sinica B, 2024 - Elsevier
Cancer reprogramming is an important facilitator of cancer development and survival, with
tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation …

The mechanism of Warburg effect-induced chemoresistance in cancer

C Liu, Y **, Z Fan - Frontiers in oncology, 2021 - frontiersin.org
Although chemotherapy can improve the overall survival and prognosis of cancer patients,
chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to …

Molecular targeted therapy: a new avenue in glioblastoma treatment

O El Atat, R Naser, M Abdelkhalek… - Oncology …, 2022 - spandidos-publications.com
Glioblastoma, also referred to as glioblastoma multiforme (GBM), is grade IV astrocytoma
characterized by being fast-growing and the most aggressive brain tumor. In adults, it is the …

[HTML][HTML] Role of oxidative stress in metabolic reprogramming of brain cancer

K Agrawal, S Asthana, D Kumar - Cancers, 2023 - mdpi.com
Simple Summary According to Globocan 2020 data, approximately 308,102 new cases of
brain cancer and central nervous system (CNS) cancers were reported worldwide, with …

The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability

N Ravn-Boess, N Roy, T Hattori, D Bready… - Cell reports, 2023 - cell.com
Glioblastoma (GBM) is the most common and aggressive primary brain malignancy.
Adhesion G protein-coupled receptors (aGPCRs) have attracted interest for their potential as …

Noncoding RNAs in the glycolysis of ovarian cancer

C Zhang, N Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
Energy metabolism reprogramming is the characteristic feature of tumors. The
tumorigenesis, metastasis, and drug resistance of ovarian cancer (OC) is dependent on …

The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression

B Yan, X Li, M Peng, Y Zuo, Y Wang, P Liu… - … & Molecular Medicine, 2023 - nature.com
Aberrant glucose metabolism is a characteristic of bladder cancer. Hyperglycemia
contributes to the development and progression of bladder cancer. However, the underlying …