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Pre-eclampsia: pathogenesis, novel diagnostics and therapies
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …
[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …
Pre‐eclampsia‐like syndrome induced by severe COVID‐19: a prospective observational study
Objectives To investigate the incidence of clinical, ultrasonographic and biochemical
findings related to pre‐eclampsia (PE) in pregnancies with COVID‐19, and to assess their …
findings related to pre‐eclampsia (PE) in pregnancies with COVID‐19, and to assess their …
Predictive value of the sFlt-1: PlGF ratio in women with suspected preeclampsia
Background The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor
(PlGF) is elevated in pregnant women before the clinical onset of preeclampsia, but its …
(PlGF) is elevated in pregnant women before the clinical onset of preeclampsia, but its …
Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 …
Background Existing evidence on the effects of race and ethnicity on pregnancy outcomes is
restricted to individual studies done within specific countries and health systems. We aimed …
restricted to individual studies done within specific countries and health systems. We aimed …
Combining biomarkers to predict pregnancy complications and redefine preeclampsia: the angiogenic-placental syndrome
H Stepan, M Hund, T Andraczek - Hypertension, 2020 - ahajournals.org
Placental dysfunction underlies a spectrum of perinatal pathologies, including preeclampsia
and fetal growth restriction. Angiogenesis-related factors, including sFlt-1 (soluble fms-like …
and fetal growth restriction. Angiogenesis-related factors, including sFlt-1 (soluble fms-like …
The competing risk approach for prediction of preeclampsia
The established method of the assessment of the risk for development of preeclampsia is to
identify risk factors from maternal demographic characteristics and medical history; in the …
identify risk factors from maternal demographic characteristics and medical history; in the …
Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study
Background—Hypertensive disorders of pregnancy are a major contributor to death and
disability for pregnant women and their infants. The diagnosis of preeclampsia by using …
disability for pregnant women and their infants. The diagnosis of preeclampsia by using …
[HTML][HTML] Systematic development of ionizable lipid nanoparticles for placental mRNA delivery using a design of experiments approach
Ionizable lipid nanoparticles (LNPs) have gained attention as mRNA delivery platforms for
vaccination against COVID-19 and for protein replacement therapies. LNPs enhance mRNA …
vaccination against COVID-19 and for protein replacement therapies. LNPs enhance mRNA …
A literature review and best practice advice for second and third trimester risk stratification, monitoring, and management of pre‐eclampsia: Compiled by the …
Pre-eclampsia is a multisystem disorder that typically affects 2%–5% of pregnant women
and is one of the leading causes of maternal and perinatal morbidity and mortality …
and is one of the leading causes of maternal and perinatal morbidity and mortality …