Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

B Niu, K Liao, Y Zhou, T Wen, G Quan, X Pan, C Wu - Biomaterials, 2021 - Elsevier
Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Y **ong, C **ao, Z Li, X Yang - Chemical Society Reviews, 2021 - pubs.rsc.org
Glutathione (GSH), the main redox buffer, has long been recognized as a pivotal modulator
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …

Glutathione-depleting nanomedicines for synergistic cancer therapy

X Cheng, HD Xu, HH Ran, G Liang, FG Wu - ACS nano, 2021 - ACS Publications
Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …

Nanozymes: versatile platforms for cancer diagnosis and therapy

X Zhang, X Chen, Y Zhao - Nano-Micro Letters, 2022 - Springer
Natural enzymes usually suffer from high production cost, ease of denaturation and
inactivation, and low yield, making them difficult to be broadly applicable. As an emerging …

[HTML][HTML] Fluorescent-based nanosensors for selective detection of a wide range of biological macromolecules: A comprehensive review

S Sargazi, I Fatima, MH Kiani… - International Journal of …, 2022 - Elsevier
Thanks to their unique attributes, such as good sensitivity, selectivity, high surface-to-volume
ratio, and versatile optical and electronic properties, fluorescent-based bioprobes have been …

[HTML][HTML] Tailoring gold nanocluster properties for biomedical applications: From sensing to bioimaging and theranostics

SM Farkhani, P Dehghankelishadi, A Refaat… - Progress in Materials …, 2024 - Elsevier
Gold nanomaterials have emerged as versatile systems which hold a great promise for
several biomedical applications. Among them, gold nanoclusters (AuNCs)—ultra-small …

Gold nanoclusters for theranostic applications

Y Zheng, J Wu, H Jiang, X Wang - Coordination Chemistry Reviews, 2021 - Elsevier
Gold nanoclusters, consisting of a few to several hundred Au atoms with a core size below 2
nm, have attracted worldwide attention in the biomedicine because of their supernormal …

Monodisperse gold nanoparticles: A review on synthesis and their application in modern medicine

MA Dheyab, AA Aziz, P Moradi Khaniabadi… - International Journal of …, 2022 - mdpi.com
Gold nanoparticles (AuNPs) are becoming increasingly popular as drug carriers due to their
unique properties such as size tenability, multivalency, low toxicity and biocompatibility …

Next-generation engineered nanogold for multimodal cancer therapy and imaging: a clinical perspectives

M Alle, G Sharma, SH Lee, JC Kim - Journal of nanobiotechnology, 2022 - Springer
Cancer is one of the significant threats to human life. Although various latest technologies
are currently available to treat cancer, it still accounts for millions of death each year …

Metal nanoclusters as biomaterials for bioapplications: atomic precision as the next goal

J Yang, F Yang, C Zhang, X He, R ** - ACS Materials Letters, 2022 - ACS Publications
Noble metal nanoclusters (NCs) have emerged as a new class of nanomaterials which have
great potential in bioapplications. Due to their ultrasmall size and versatile surface …