Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy
B Niu, K Liao, Y Zhou, T Wen, G Quan, X Pan, C Wu - Biomaterials, 2021 - Elsevier
Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …
Engineering nanomedicine for glutathione depletion-augmented cancer therapy
Y **ong, C **ao, Z Li, X Yang - Chemical Society Reviews, 2021 - pubs.rsc.org
Glutathione (GSH), the main redox buffer, has long been recognized as a pivotal modulator
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …
Glutathione-depleting nanomedicines for synergistic cancer therapy
X Cheng, HD Xu, HH Ran, G Liang, FG Wu - ACS nano, 2021 - ACS Publications
Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …
Nanozymes: versatile platforms for cancer diagnosis and therapy
X Zhang, X Chen, Y Zhao - Nano-Micro Letters, 2022 - Springer
Natural enzymes usually suffer from high production cost, ease of denaturation and
inactivation, and low yield, making them difficult to be broadly applicable. As an emerging …
inactivation, and low yield, making them difficult to be broadly applicable. As an emerging …
[HTML][HTML] Fluorescent-based nanosensors for selective detection of a wide range of biological macromolecules: A comprehensive review
Thanks to their unique attributes, such as good sensitivity, selectivity, high surface-to-volume
ratio, and versatile optical and electronic properties, fluorescent-based bioprobes have been …
ratio, and versatile optical and electronic properties, fluorescent-based bioprobes have been …
[HTML][HTML] Tailoring gold nanocluster properties for biomedical applications: From sensing to bioimaging and theranostics
Gold nanomaterials have emerged as versatile systems which hold a great promise for
several biomedical applications. Among them, gold nanoclusters (AuNCs)—ultra-small …
several biomedical applications. Among them, gold nanoclusters (AuNCs)—ultra-small …
Gold nanoclusters for theranostic applications
Y Zheng, J Wu, H Jiang, X Wang - Coordination Chemistry Reviews, 2021 - Elsevier
Gold nanoclusters, consisting of a few to several hundred Au atoms with a core size below 2
nm, have attracted worldwide attention in the biomedicine because of their supernormal …
nm, have attracted worldwide attention in the biomedicine because of their supernormal …
Monodisperse gold nanoparticles: A review on synthesis and their application in modern medicine
Gold nanoparticles (AuNPs) are becoming increasingly popular as drug carriers due to their
unique properties such as size tenability, multivalency, low toxicity and biocompatibility …
unique properties such as size tenability, multivalency, low toxicity and biocompatibility …
Next-generation engineered nanogold for multimodal cancer therapy and imaging: a clinical perspectives
M Alle, G Sharma, SH Lee, JC Kim - Journal of nanobiotechnology, 2022 - Springer
Cancer is one of the significant threats to human life. Although various latest technologies
are currently available to treat cancer, it still accounts for millions of death each year …
are currently available to treat cancer, it still accounts for millions of death each year …
Metal nanoclusters as biomaterials for bioapplications: atomic precision as the next goal
J Yang, F Yang, C Zhang, X He, R ** - ACS Materials Letters, 2022 - ACS Publications
Noble metal nanoclusters (NCs) have emerged as a new class of nanomaterials which have
great potential in bioapplications. Due to their ultrasmall size and versatile surface …
great potential in bioapplications. Due to their ultrasmall size and versatile surface …