The complex genetic architecture of Alzheimer's disease: novel insights and future directions
Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …
disorder and the most common form of dementia. AD is highly heritable, with heritability …
Towards a future where Alzheimer's disease pathology is stopped before the onset of dementia
WM van der Flier, ME de Vugt, EMA Smets, M Blom… - Nature aging, 2023 - nature.com
Alzheimer's disease (AD) is a major healthcare challenge with no curative treatment at
present. To address this challenge, we need a paradigm shift, where we focus on pre …
present. To address this challenge, we need a paradigm shift, where we focus on pre …
A global view of the genetic basis of Alzheimer disease
The risk of Alzheimer disease (AD) increases with age, family history and informative genetic
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease
The integration of quantitative trait loci (QTLs) with disease genome-wide association
studies (GWASs) has proven successful in prioritizing candidate genes at disease …
studies (GWASs) has proven successful in prioritizing candidate genes at disease …
Step by step: towards a better understanding of the genetic architecture of Alzheimer's disease
Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …
of this component has progressed over the last 10 years, thanks notably to the advent of …
The genetic regulation of protein expression in cerebrospinal fluid
Studies of the genetic regulation of cerebrospinal fluid (CSF) proteins may reveal pathways
for treatment of neurological diseases. 398 proteins in CSF were measured in 1,591 …
for treatment of neurological diseases. 398 proteins in CSF were measured in 1,591 …
[HTML][HTML] Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer's disease
The integration of quantitative trait loci (QTL) with disease genome-wide association studies
(GWAS) has proven successful at prioritizing candidate genes at disease-associated loci …
(GWAS) has proven successful at prioritizing candidate genes at disease-associated loci …
Factors Affecting Resilience and Prevention of Alzheimer's Disease and Related Dementias
Alzheimer's disease (AD) is a devastating, age‐associated neurodegenerative disorder and
the most common cause of dementia. The clinical continuum of AD spans from preclinical …
the most common cause of dementia. The clinical continuum of AD spans from preclinical …
Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center
Abstract The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington
University in St. Louis has pioneered and led worldwide seminal studies that have …
University in St. Louis has pioneered and led worldwide seminal studies that have …
Genetics of Alzheimer's disease in the African American population
Black/African American (AA) individuals have a higher risk of Alzheimer's disease (AD) than
White non-Hispanic persons of European ancestry (EUR) for reasons that may include …
White non-Hispanic persons of European ancestry (EUR) for reasons that may include …