The Rho-family proteins make up a major branch of the Ras superfamily of small GTPases.
To date, 22 human genes encoding at least 25 proteins have been described. The best …

The movement of cancer cells into tissue surrounding the tumour and the vasculature is the
first step in the spread of metastatic cancers. Recent advances in imaging, the use of 3D …

Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no
significant therapeutic progress made in the past 50 years. Recent studies suggest that …

Exosomes are small secreted vesicles that can transfer their content to recipient cells. In
cancer, exosome secretion has been implicated in tumor growth and metastatic spread. In …

Reactivation of telomerase, the chromosome end–replicating enzyme, drives human cell
immortality and cancer. Point mutations in the telomerase reverse transcriptase (TERT) gene …

The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPase function. GDIs
control the access of Rho GTPases to regulatory guanine nucleotide exchange factors and …

Metastasis is the main cause of cancer mortality for many types of cancer; however,
difficulties remain in effectively preventing metastasis. It has been recently and widely …

Tumour metastasis is a significant contributor to death in cancer patients. Eight metastasis-
suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without …

Invasion of neighboring extracellular matrix tissue, the lymphatic system and blood vessels
is a key element of tumor cell metastasis in many epithelial tumors. Understanding the cell …

Identification of the key regulatory molecules in metastasis is crucial for understanding tumor
dissemination and for the development of novel interventions. The recent identification of …